Recombinant Human CCNA1 Protein, MYC/DDK-tagged

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Recombinant Human CCNA1 Protein, MYC/DDK-tagged

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Cat.No. : CCNA1-2996H
Product Overview : Recombinant Human CCNA1 protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293.
Description : The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 52.2 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : CCNA1 cyclin A1 [ Homo sapiens ]
Official Symbol : CCNA1
Synonyms : CT146
Gene ID : 8900
mRNA Refseq : NM_001111045
Protein Refseq : NP_001104515
MIM : 604036
UniProt ID : P78396

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