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Recombinant Human CCS Protein, with Cu (I)

Cat.No.: CCS-483H
Product Overview: Recombinant full length Human Cu (I)-CCS (aa 1-274)(Copper chaperone for superoxide dismutase) with a GSFT sequence at N-terminal was expressed in E. coli. Binding of 2 Cu (I) to the protein was confirmed by ICP.
Description: Copper chaperone for superoxide dismutase specifically delivers Cu to copper/zinc superoxide dismutase and may activate copper/zinc superoxide dismutase through direct insertion of the Cu cofactor.
Source: E. coli
Species: Human
Form: In 20 mM Phosphate buffer pH 7.0.
Molecular Mass: 29.4 kDa
Protein length: aa 1-274
AA Sequence: GMSF-MASDSGNQGT LCTLEFAVQM TCQSCVDAVR KSLQGVAGVQ DVEVHLEDQM VLVHTTLPSQ EVQALLEGTG RQAVLKMGS GQLQNLGAAV AILGGPGTVQ GVVRFLQLTP ERCLIEGTID GLEPGLHGLH VHQYGDLTMM CNSCGNHFNP DGASHGGPQD SDRHRGDLGN VRADADGRAI FRMEDEQLKV WDVIGRSLII DEGEDDLGRG GHPLSKITGN SGERLACGII ARSAGLFQNP KQICSCDGLT IWEERGRPIA GKGRKESAQP PAHL
Purity: >95% by SDS-PAGE. The protein was observed as a single band migrating at a molecular weight > 25 kDa and < 35 kDa.
Notes: To avoid oxidation and leaking of the Cu(I) bound to the protein, keep and use the sample under inert atomosphere.
Storage: Store at - 20 centigrade. The protein is stable at 4 centigrade for at least 2 weeks and at 25 centigrade for at least several hours. After initial deforst, aliquot product into individual tubes under inert atomosphere and refreeze at - 20 centigrade. Avoid repeated freeze/defrost cycles. Avoid exposition to air.
Concentration: 1 mg/ml
Gene Name: CCS copper chaperone for superoxide dismutase [ Homo sapiens ]
Official Symbol: CCS
Synonyms: CCS; copper chaperone for superoxide dismutase; superoxide dismutase copper chaperone; MGC138260;
Gene ID: 9973
mRNA Refseq: NM_005125
Protein Refseq: NP_005116
MIM: 603864
UniProt ID: O14618
Chromosome Location: 11
Pathway: Amyotrophic lateral sclerosis (ALS), organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), conserved biosystem;
Function: copper ion binding; copper ion transmembrane transporter activity; metal ion binding; protein binding; NOT superoxide dismutase activity; superoxide dismutase copper chaperone activity; zinc ion binding;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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