| Description : |
Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4+ CD56+ leukemic tumor cells. |
| Source : |
E. coli |
| Species : |
Human |
| Tag : |
His |
| Molecular Mass : |
~110 kDa |
| AA Sequence : |
MQREVTVQKGPLFRAEGYPVSIGCN VTGHQGPSEQHFQWSVYLPTNPTQE VQIISTKDAAFSYAVYTQRVRSGDV YVERVQGNSVLLHISKLQMKDAGEY ECHTPNTDEKYYGSYSAKTNLIVIP DTLSATMSSQTLGKEEGEPLALTCE ASKATAQHTHLSVTWYLTQDGGGSQ ATEIISLSKDFILVPGPLYTERFAA SDVQLNKLGPTTFRLSIERLQSSDQ GQLFCEATEWIQDPDETWMFITKKQ TDQTTLRIQPAVKDFQVNITADSLF AEGKPLELVCLVVSSGRDPQLQGIW FFNGTEIAHIDAGGVLGLKNDYKER ASQGELQVSKLGPKAFSLKIFSLGP EDEGAYRCVVAEVMKTRTGSWQVLQ RKQSPDSHVHLRKPAARSVVMSTKN KQQVVWEGETLAFLCKAGGAESPLS VSWWHIPRDQTQPEFVAGMGQDGIV QLGASYGVPSYHGNTRLEKMDWATF QLEITFTAITDSGTYECRVSEKSRN QARDLSWTQKISVTVKSLESSLQVS LMSRQPQVMLTNTFDLSCVVRAGYS DLKVPLTVTWQFQPASSHIFHQLIR ITHNGTIEWGNFLSRFQKKTKVSQS LFRSQLLVHDATEEETGVYQCEVEV YDRNSLYNNRPPRASAISHPLRIAV TLPESKLKVNSRSQVQELSINSNTD IECSILSRSNGNLQLAIIWYFSPVS TNASWLKILEMDQTNVIKTGDEFHT PQRKQKFHTEKVSQDLFQLHILNVE DSDRGKYHCAVEEWLLSTNGTWHKL GEKKSGLTELKLKPTGSKVRVSKVY WTENVTEHREVAIRCSLESVGSSAT LYSVMWYWNRENSGSKLLVHLQHDG LLEYGEEGLRRHLHCYRSSSTDFVL KLHQVEMEDAGMYWCRVAEWQLHGH PSKWINQASDESQRMVLTVLPSEPT LPSRICSSAPLE |
| Purity : |
Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE). |
| Notes : |
For research use only, not for use in diagnostic procedure. |
| Storage : |
Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles. |
| Storage Buffer : |
PBS, 4M Urea, pH7.4 |
