Recombinant Human CD109 Protein, C-His-tagged

• Cat.No.: CD109-018H
• Product Overview: Recombinant Human CD109 Protein with C-His tag was expressed in E. coli.

Specification

• Description: CD109 is a glycosylphosphatidylinositol (GPI)-linked glycoprotein that belongs to the alpha2-macroglobulin family of thioester containing proteins. CD109 is associated with TGF-beta receptor I (TbRI) and inhibits TGF-beta signaling. Cleavage of CD109 at its Furin cleavage site results in the release of its large amino-terminal domain, which then binds to the TGF-beta receptor I to inhibit TGF-beta signaling. CD109 is expressed on a subset of CD34+ bone marrow cells and mesenchymal stem cells, activated platelets, activated T cells, endothelial cells, and a wide variety of tumors. Elevated CD109 expression has been considered a diagnostic/prognostic marker for several types of cancers.
• Source: E. coli
• Species: Human
• Tag: His
• Molecular Mass: ~36 kDa
• AA Sequence: LSSVGSPKAKEALNMLTWRAEQEGG MQFWVSSESKLSDSWQPRSLDIEVA AYALLSHFLQFQTSEGIPIMRWLSR QRNSLGGFASTQDTTVALKALSEFA ALMNTERTNIQVTVTGPSSPSPVKF LIDTHNRLLLQTAELAVVQPTAVNI SANGFGFAICQLNVVYNVKASGSSR RRRSIQNQEAFDLDVAVKENKDDLN HVDLNVCTSFSGPGRSGMALMEVNL LSGFMVPSEAISLSETVKKVEYDHG KLNLYLDSVNETQFCVNIPAVRNFK VSNTQDASVSIVDYYEPRRQAVRSY NSEVKLSSCDLCSDVQGCRPCEDGA
• Purity: Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE).
• Notes: For research use only, not for use in diagnostic procedure.
• Storage: Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles.
• Concentration: ≥0.5 mg/mL
• Storage Buffer: PBS, 4M Urea, pH7.4

Gene Information

• Gene Name: CD109 CD109 molecule [ Homo sapiens (human) ]
• Official Symbol: CD109
• Synonyms: CD109; CD109 molecule; CD109 antigen (Gov platelet alloantigens); CD109 antigen; CPAMD7; DKFZp762L1111; FLJ38569; p180; r150; Gov platelet alloantigens; activated T-cell marker CD109; platelet-specific Gov antigen; 150 kDa TGF-beta-1-binding protein; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7; RP11-525G3.1; FLJ41966
• Gene ID: 135228
• mRNA Refseq: NM_001159587
• Protein Refseq: NP_001153059
• MIM: 608859
• UniProt ID: Q6YHK3