Recombinant Human CD109 Protein, Fc Tagged

• Cat.No.: CD109-11229H
• Product Overview: Human CD109 protein, Fc Tag is expressed from human 293 cells (HEK293). It contains AA Val 22-Ser 1269 (Accession # Q6YHK3-1). This protein carries a human IgG1 Fc tag at the C-terminus. Predicted N-terminus: Val 22

Specification

• Species: Human
• Source: HEK293
• Tag: Fc
• Protein Length: 22-1269 aa
• Description: CD109 is a glycosyl phosphatidylinositol (GPI)-linked glycoprotein that localizes to the surface of platelets, activated T-cells, and endothelial cells. CD109 is expressed in many malignant tumors, including various squamous cell carcinomas and adenocarcinomas, and plays a role as a multifunctional coreceptor.CD109 reportedly associates with transforming growth factor (TGF)-β receptors and negatively regulates TGF-β signaling in keratinocytes. Additionally, CD109 is potentially related to signal transducer and activator of transcription-3 signaling and aberrant cell proliferation.
• Form: Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 with trehalose as protectant.
• Molecular Mass: The protein has a calculated MW of 166.2 kDa. The protein migrates as >180 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Endotoxin: Less than 1.0 EU/μg by the LAL method/rFC method.
• Purity: >90% as determined by SDS-PAGE.
• Storage: This product is stable after storage at: -20 to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 μg/μL. Centrifuge the vial at 4 centigrade before opening to recover the entire contents.

Gene Information

• Gene Name: CD109 CD109 molecule [ Homo sapiens (human) ]
• Official Symbol: CD109
• Synonyms: CD109; CD109 molecule; CD109 antigen (Gov platelet alloantigens); CD109 antigen; CPAMD7; DKFZp762L1111; FLJ38569; p180; r150; Gov platelet alloantigens; activated T-cell marker CD109; platelet-specific Gov antigen; 150 kDa TGF-beta-1-binding protein; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7; RP11-525G3.1; FLJ41966
• Gene ID: 135228
• mRNA Refseq: NM_001159587
• Protein Refseq: NP_001153059
• MIM: 608859
• UniProt ID: Q6YHK3