| Species : |
Human |
| Source : |
CHO |
| Tag : |
His |
| Protein Length : |
20-291 |
| Description : |
B-lymphocyte antigen CD19 is a type I transmembrane protein present on all B cells and is a dominant signaling component of mature B cells. CD19 acts as a critical coreceptor for B cell receptor (BCR) signal transduction by recruiting and amplifying the activation of Src-family protein tyrosine kinases such as Lyn and Fyn. CD19 also enhances BCR-induced signaling crucial for B cell expansion through recruitment and activation of PI3K and downstream AKT kinases. CD19-deficient humans and mice exhibit hypo-responsiveness to transmembrane signals, and weak T cell-dependent humoral responses, leading to an overall impaired immune response. |
| Molecular Mass : |
Observed MW: ~50-65 kDa.
Calculated MW: ~31 kDa. |
| Purity : |
The purity of CD19 was determined to be ~ 75 % by densitometry. |
| Stability : |
One year at -70 centigrade from date of shipment. |
| Storage : |
Store product at -70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
| Concentration : |
0.2 μg/μL |
| Storage Buffer : |
Recombinant protein stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.25mM DTT, 25% glycerol. |
| Shipping : |
Dry ice |
