Recombinant Human CD200 Receptor 1-Like, His-tagged

• Cat.No.: CD200R1L-3918H
• Product Overview: A DNA sequence encoding the human CD200R1L ( NP_001008784.2 ) extracellular domain ( Met 1-Leu 239, one aa mutation 113Arg/Leu ) was expressed, fused with a polyhistidine tag at the C-terminus.

Specification

• Cat. No.: CD200R1L-3918H
• Description: Cell surface glycoprotein CD200 receptor 2, also known as Cell surface glycoprotein CD200 receptor 1-like, Cell surface glycoprotein OX2 receptor 2, CD200 receptor-like 2, CD200Rla, CD200R1L and CD200R2, is a single-pass type I membrane protein which belongs to the CD200R family. CD200R1L/CD200R2.
• Source: Human
• Host: Human Cells
• Form: Lyophilized from sterile PBS, pH 7.4
• Purity: > 95 % as determined by SDS-PAGE
• Endotoxin: < 1.0 EU per μg protein as determined by the LAL method
• Stability: Samples are stable for up to twelve months from date of receipt at -70°C.
• Predicted N terminal: Gly 24
• Molecular Mass: The recombinant human CD200R1L consists of 227 amino acids and predictes a molecular mass of 25.2 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh CD200R1L is approximately 45-60 KDa due to glycosylation.
• Storage: Store it under sterile conditions at -70°C upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage.
• Protein length: Met1-Leu239

Gene Information

• Gene Name: CD200R1L receptor 1-like [ Homo sapiens ]
• Official Symbol: CD200R1L
• Synonyms: CD200R1L; CD200 receptor 1-like; CD200R2; CD200RLa; cell surface glycoprotein CD200 receptor 2; huCD200R2; CD200 receptor 2; OTTHUMP00000214680; OTTHUMP00000214681; CD200 receptor-like 2; cell surface glycoprotein OX2 receptor 2; CD200 cell surface glycoprotein receptor 2; CD200 cell surface glycoprotein receptor-like 2; CD200 cell surface glycoprotein receptor-like a; cell surface glycoprotein CD200 receptor 1-like
• Gene ID: 344807
• mRNA Refseq: NM_001008784
• Protein Refseq: NP_001008784
• UniProt ID: Q6Q8B3
• Chromosome Location: 3q13
• Function: receptor activity

Reviews

10/27/2022

The wide range of applications of CD200R1L shows its important role in scientific research and provides strong support for scientific research.

07/06/2021

After using CD200R1L, the background of the Western blot was very clean with no nonspecific signal.

01/08/2020

This stability of CD200R1L was still very good in the process of performing complex biological experiments, indicating that it has excellent within-batch and between-batch stability.

Q&As

How does the expression level of CD200R1L protein change during the development of the disease?

The expression level of CD200R1L proteins may change during the development and progression of certain diseases. For example, in some immune diseases, the expression level of CD200R1L may be down-regulated, leading to increased immune cell activity and an intensified inflammatory response. However, the association between specific changes and different diseases and the regulatory mechanism need further research to clarify.

What are the methods of up-regulating and down-regulating CD200R1L protein?

Up-regulation and down-regulation of CD200R1L proteins can be achieved through a variety of pathways. For example, specific agonists or inhibitors can be used to modulate the signaling pathways of CD200R1L, affecting their expression and function. In addition, certain cytokines and extracellular signaling molecules may also play regulatory roles by influencing the expression of CD200R1L. Specific up-regulation and down-regulation methods need to select appropriate strategies according to the research purpose and experimental conditions.

Is there a link between gene polymorphisms in CD200R1L proteins and susceptibility to disease?

Polymorphisms in CD200R1L genes may be associated with susceptibility to certain diseases, but this is currently not well studied. Some studies suggest that polymorphismic variations in CD200R1L genes may affect the expression level, function, and interaction with the ligand CD200, thereby affecting immunomodulatory processes. However, more research is needed to verify this association.

What is the relationship between CD200R1L protein and tumor immune escape?

CD200R1L proteins play a role in tumor immune evasion. Studies have found that some tumor cells can inhibit the activity of CD200R1L-positive immune cells (such as macrophages, dendritic cells, etc.) by expressing CD200 ligands highly, reducing the killing effect of immune cells on tumor cells, thereby promoting tumor growth and metastasis. The regulation of CD200R1L signaling pathways may help reverse tumor immune escape and improve the effectiveness of tumor immunotherapy.

How does CD200R1L protein play a role in immune tolerance?

It play a role in inhibiting the activity of immune cells in immune tolerance. After binding to its ligand CD200, CD200R1L reduces the production of pro-inflammatory cytokines by inhibiting the activation signaling pathway of immune cells, thereby regulating the intensity of the immune response, maintaining the balance of the immune system, and preventing tissue damage caused by excessive immune response.

What is the potential application value of CD200R1L protein in immunotherapy?

CD200R1L proteins have potential applications in immunotherapy. Studies have shown that by regulating CD200R1L signaling pathways, immune cells can enhance the ability of immune cells to attack tumor cells and improve the effect of immunotherapy. In addition, the regulatory role of CD200R1L in autoimmune diseases may also provide new ideas for the treatment of related diseases.