Recombinant Human CD24 protein, GST/His-tagged

• Cat.No.: CD24-265H
• Product Overview: Recombinant Human CD24 fused with N-terminal GST and C-terminal His was expressed in E. coli.

Specification

• Description: This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and B cells and modulates growth and differentiation signals to these cells. The precursor protein is cleaved to a short 32 amino acid mature peptide which is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. This gene was missing from previous genome assemblies, but is properly located on chromosome 6. Non-transcribed pseudogenes have been designated on chromosomes 1, 15, 20, and Y. Alternative splicing results in multiple transcript variants.
• Source: E.coli
• Species: Human
• Tag: His&GST
• Form: 25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1% Sarkosyl.
• Molecular Mass: 34.1kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: CD24 CD24 molecule [ Homo sapiens ]
• Official Symbol: CD24
• Synonyms: CD24; CD24 molecule; CD24 antigen (small cell lung carcinoma cluster 4 antigen); signal transducer CD24; CD24A; FLJ22950; FLJ43543; MGC75043
• Gene ID: 100133941
• mRNA Refseq: NM_013230
• Protein Refseq: NP_037362
• MIM: 600074
• UniProt ID: P25063

Reviews

10/31/2022

The technician guided me through the process, which led to satisfactory results.

10/18/2022

Prompt delivery helped me get satisfactory experimental results in a short period of time.

07/18/2021

The protein composition was stable and concentrated, allowing me to obtain satisfactory experimental results.

Q&As

What are the effects of overexpressing CD24?

Overexpression of CD24 increases the proliferation, migration and invasion of breast cancer cells.

What diseases is CD24 relevant to the study of?

CD24 has been closely associated with the study of diseases such as oral squamous cell carcinoma, breast cancer and gastric cancer.

How do CD24 expression levels change in breast cancer tissues?

CD24 expression was higher in breast cancer tissues compared to normal breast tissues.

Where is CD24 primarily expressed?

CD24 is expressed on the surface of different cell types, including myeloid cells, keratinocytes, and macrophages.

What are the effects of blocking the expression of CD24?

Tumor growth was retarded after blocking CD24 expression.

What biological processes is CD24 involved in?

CD24 regulates tumor cell growth and proliferation, metastasis and invasion by participating in relevant signal transduction pathways that mediate tumorigenesis and development.

How is CD24 related to the inhibitory receptor Siglec-10?

CD24 binds to the inhibitory receptor Siglec-10.