Recombinant Human CD24 protein, mFc-tagged

• Cat.No.: CD24-063H
• Product Overview: Human CD24 is expressed from mammalian with a mFc tag at the C-terminal. It contains Ser27-Gly59.

Specification

• Description: CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils and neutrophil precursors from the myelocyte stage onwards. The potential for targeting CD24 in cancer therapy seems promising, as CD24 is overexpressed in many human cancers.
• Source: HEK293
• Species: Human
• Tag: mFc
• Form: Supplied as 0.22um filtered solution in PBS (pH 7.4).
• Molecular Mass: The protein has a predicted MW of 29.5 kDa.Due to glycosylation, the protein migrates to 48- 58KDa based on Bis-Tris PAGE result.
• Protein length: It contains Ser27-Gly59.
• Endotoxin: Less than 0.001EU per ug by the LAL method.
• Purity: > 95% as determined by SDS-PAGE; > 95% as determined by HPLC
• Storage: The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.

Gene Information

• Gene Name: CD24 CD24 molecule [ Homo sapiens ]
• Official Symbol: CD24
• Synonyms: CD 24; CD24 antigen (small cell lung carcinoma cluster 4 antigen); CD24 antigen; CD24 molecule; CD24; CD24A; CD24Asignal transducer CD24; FLJ22950; FLJ43543; MGC75043; Small cell lung carcinoma cluster 4 antigen
• Gene ID: 100133941
• mRNA Refseq: NM_013230
• Protein Refseq: NP_037362
• MIM: 600074
• UniProt ID: P25063

Reviews

10/31/2022

The technician guided me through the process, which led to satisfactory results.

10/18/2022

Prompt delivery helped me get satisfactory experimental results in a short period of time.

07/18/2021

The protein composition was stable and concentrated, allowing me to obtain satisfactory experimental results.

Q&As

What are the effects of overexpressing CD24?

Overexpression of CD24 increases the proliferation, migration and invasion of breast cancer cells.

What diseases is CD24 relevant to the study of?

CD24 has been closely associated with the study of diseases such as oral squamous cell carcinoma, breast cancer and gastric cancer.

How do CD24 expression levels change in breast cancer tissues?

CD24 expression was higher in breast cancer tissues compared to normal breast tissues.

Where is CD24 primarily expressed?

CD24 is expressed on the surface of different cell types, including myeloid cells, keratinocytes, and macrophages.

What are the effects of blocking the expression of CD24?

Tumor growth was retarded after blocking CD24 expression.

What biological processes is CD24 involved in?

CD24 regulates tumor cell growth and proliferation, metastasis and invasion by participating in relevant signal transduction pathways that mediate tumorigenesis and development.

How is CD24 related to the inhibitory receptor Siglec-10?

CD24 binds to the inhibitory receptor Siglec-10.