Recombinant Human CD274, His-tagged, Biotinylated
Cat.No. : | CD274-256H |
Product Overview : | Human PDL1 /CD274 Protein, Biotinylated (Biotinylated PDL1 / CD274) Phe 19 - Arg 238, was labeled with biotin based on rhPDL1 Protein, which was produced in human 293 cells (HEK293). |
- Specification
- Gene Information
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Description : | Programmed cell death 1 ligand 1 (PD-L1) also known as cluster of differentiation (CD274) or B7 homolog 1 (B7-H1), is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses. B7-H1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain. PD-L1 is highly expressed in the heart, skeletal muscle, placenta and lung and weakly expressed in the thymus, spleen, kidney and liver. PD-L1 is expressed on activated T-cells, B-cells, dendritic cells, keratinocytes and monocytes. PD-L1 is up-regulated on T- and B-cells, dendritic cells, keratinocytes and monocytes after LPS and IFNG activation and up-regulated in B-cells activated by surface Ig cross-linking. PD-L1 involve in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. |
Source : | HEK293 |
Species : | Human |
Tag : | His |
Form : | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Trehalose are added as protectants before lyophilization. |
Molecular Mass : | Biotinylated PDL1 / CD274, fused with 6×His tag at the C-terminus, has a calculated MW of 26 kDa. The predicted N-terminus is Phe 19. DTT-reduced Protein migrates as 35-42 kDa due to glycosylation. |
Endotoxin : | Less than 1.0 EU per μg of the Biotinylated PDL1 / CD274 by the LAL method. |
Purity : | >95% as determined by reduced SDS-PAGE. |
Storage : | Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4°C); After reconstitution under sterile conditions for 3 months (-70°C). |
Gene Name : | CD274 CD274 molecule [ Homo sapiens ] |
Official Symbol : | CD274 |
Synonyms : | CD274; CD274 molecule; CD274 antigen , PDCD1LG1, programmed cell death 1 ligand 1; programmed cell death 1 ligand 1; B7 homolog 1; B7 H; B7 H1; B7H1; PD L1; PDL1; CD274 antigen; PDCD1 ligand 1; programmed death ligand 1; B7-H; PD-L1; PDCD1L1; PDCD1LG1; MGC142294; MGC142296; |
Gene ID : | 29126 |
mRNA Refseq : | NM_014143 |
Protein Refseq : | NP_054862 |
MIM : | 605402 |
UniProt ID : | Q9NZQ7 |
Chromosome Location : | 9p24.1 |
Pathway : | Adaptive Immune System, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Costimulation by the CD28 family, organism-specific biosystem; Immune System, organism-specific biosystem; PD-1 signaling, organism-specific biosystem; |
Function : | protein binding; protein tyrosine phosphatase activity; receptor activity; |
Products Types
◆ Recombinant Protein | ||
CD274-707C | Recombinant Cynomolgus monkey CD274 Protein, Fc-tagged | +Inquiry |
CD274-199C | Recombinant Human CD274 Protein, His-tagged | +Inquiry |
Cd274-821M | Active Recombinant Mouse Cd274 protein(Met1-His239), hFc-tagged | +Inquiry |
CD274-0763H | Recombinant Human CD274 Protein, His-Flag-StrepII-Tagged | +Inquiry |
CD274-558R | Recombinant Rhesus Macaque CD274 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
CD274-914CCL | Recombinant Cynomolgus CD274 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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