Recombinant Human CD300C, Fc-tagged

• Cat.No.: CD300C-173H
• Product Overview: Recombinant Human CD300C /CLM-6 /IGSF16 Protein, With C-Fc Tag (rh CD300C /CLM-6 /IGSF16 Fc Chimera) Gly 21 - Arg 183 (Accession # AAH22279) was produced in human 293 cells (HEK293).

Specification

• Species: Human
• Source: HEK293
• Tag: Fc
• Protein Length: 21-183 a.a.
• Description: CMRF35-like molecule 6 (CLM-6) is also known as CD300 antigen-like family member C, CMRF35-A1, Immunoglobulin superfamily member 16 (IgSF16) , CD antigen CD300c, which belongs to the CD300 family. CLM-6 contains one Ig-like V-type (immunoglobulin-like) domain. CD300a/c RNA and surface expression were downregulated after stimulation of plasmacytoid dendritic cells (pDCs) with TLR7 and TLR9 ligands. Exogenous interferon (IFN)-alpha down-regulated CD300a/c expression. CD300a and CD300c play an important role in the cross-regulation of TNF-alpha and IFN-alpha secretion from pDCs. CD300a and CD300c are indistinguishable on the surface of NK cells.
• Form: Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM glycine, pH7.5. Normally Mannitol or Trehalose are added as protectants before lyophilization.
• Molecular Mass: rh CD300C /CLM-6 /IGSF16 Fc Chimera is fused with human IgG1 Fc tag at the C-terminus, and has a calculated MW of 44.5 kDa. The predicted N-terminus is Gly 21. DTT-reduced Protein migrates as 60-70 kDa in SDS-PAGE due to glycosylation.
• Endotoxin: Less than 1.0 EU per μg of the rh CD300C /CLM-6 /IGSF16 Fc Chimera by the LAL method.
• Purity: >92% as determined by SDS-PAGE.
• Storage: Avoid repeated freeze-thaw cycles.No activity loss was observed after storage at:In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC).
• Reconstitution: See Certificate of Analysis for reconstitution instructions and specific concentrations.

Gene Information

• Gene Name: CD300C CD300c molecule [ Homo sapiens ]
• Official Symbol: CD300C
• Synonyms: CD300C; CD300c molecule; CD300c antigen; CMRF35-like molecule 6; CMRF 35A; CMRF35; CMRF35A; IGSF16; LIR; CMRF35 antigen; CD300 antigen-like family member C; immunoglobulin superfamily member 16; CMRF35 leukocyte immunoglobulin-like receptor; CMRF35A leukocyte immunoglobulin-like receptor; CLM-6; CMRF-35; CMRF-35A; CMRF35A1; CMRF35-A1
• Gene ID: 10871
• mRNA Refseq: NM_006678
• Protein Refseq: NP_006669
• MIM: 606786
• UniProt ID: Q08708
• Chromosome Location: 17q25.2
• Function: receptor activity; transmembrane signaling receptor activity