| Description : |
Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro). |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
25.29 kDa |
| AA Sequence : |
MPLLLLLPLLWADLTHRPKILIPGT LEPGHSKNLTCSVSWACEQGTPPIF SWLSAAPTSLGPRTTHSSVLIITPR PQDHGTNLTCQVKFAGAGVTTERTI QLNVTYVPQNPTTGIFPGDGSGKQE TRAGVVHGAIGGAGVTALLALCLCL IFFIVKTHRRKAARTAVGRNDTHPT TGSASPKHQKKSKLHGPTETSSCSG AAPTVEMDEELHYASLNFHGMNPSK DTSTEYSEVRTQTRTRPLEQKLISE EDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
