Recombinant Human CD3E Protein (198 AA), C-Fc-tagged
Cat.No. : | CD3E-30H |
Product Overview : | Recombinant Human CD3E Protein (198 aa) with a C-Fc tag was expressed in HEK293. |
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Description : | Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region. |
Source : | HEK293 |
Species : | Monkey |
Tag : | Fc |
Form : | Lyophilized, Sterile-filtered colorless solution |
Molecular Mass : | 22149 kDa |
Protein length : | 198 aa |
AA Sequence : | MQSGTRWRVLGLCLLSIGVWGQDGN EEMGSITQTPYQVSISGTTVILTCS QHLGSEAQWQHNGKNKEDSGDRLFL PEFSEMEQSGYYVCYPRGSNPEDAS HHLYLKARVCENCMEMDVMAVATIV IVDICITLGLLLLVYYWSKNRKAKA KPVTRGAGAGGRQRGQNKERPPPVP NPDYEPIRKGQQDLYSGLNQRRI |
Purity : | >98% |
Stability : | This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
Storage : | At -20 centigrade |
Concentration : | 1 mg/mL |
Storage Buffer : | PBS, pH 7.4-7.5 |
Reconstitution : | Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
Gene Name : | CD3E CD3e molecule, epsilon (CD3-TCR complex) [ Macaca mulatta ] |
Official Symbol : | CD3E |
Synonyms : | CD3E; CD3e molecule, epsilon (CD3-TCR complex); T-cell surface glycoprotein CD3 epsilon chain |
Gene ID : | 699467 |
mRNA Refseq : | XM_015115816 |
Protein Refseq : | XP_014971302 |
UniProt ID : | G7NCB9 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewManufacturers with the capacity for bulk production can offer CD3E protein in larger quantities, which is advantageous for researchers working on large-scale experiments or collaborations.
bulk production often leads to economies of scale, making the CD3E protein more cost-effective for research budgets.
Manufacturers can actively seek collaborations and partnerships with researchers to develop new applications or optimize methodologies using CD3E protein.
Q&As (5)
Ask a questionYes, CD3E levels and T-cell function can be monitored to evaluate the response to cancer immunotherapies like checkpoint inhibitors.
There are currently no approved therapies that directly target CD3E, but it is a target for research in developing immunotherapies and cancer treatments.
There may be ongoing clinical trials using CD3E-targeted therapies in the context of cancer and autoimmune diseases. It's important to check clinical trial databases for specific studies.
Yes, monitoring CD3E levels in HIV-infected individuals can provide valuable information about the progression of the disease and the effectiveness of antiretroviral therapy.
CD3E can be used in research to study T-cell responses in allergic conditions, helping to better understand and diagnose allergies.
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