Recombinant Human CD4, Fc Chimera

• Cat.No.: CD4-3030H
• Product Overview: Recombinant human CD4 Fc Chimera (rhCD4-Fc) Lys26-Trp390 fused with Fc fragment Of human IgG1 at the C-terminal,was expressed in human HEK293 cells and purified by using conventional chromatography techniques.

Specification

• Species: Human
• Source: HEK293
• Tag: Fc
• Description: This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene.
• Purity: >95% as determined by SDS-PAGE. All lots are greater than 90% pure.
• Molecular Weight: 68 kDa
• Formulation: Bulk protein in a 0.22 μm filtered solution of 50 mM Tris, 100 mM Glycine, pH 7.0 and delivered as liquid formulation or lyophilized powder.Normally 5-8% trehalose and mannitol are added as protectants before lyophilization.
• Predicted N-terminal: Lys26
• Endotoxin: Less than 1.0 EU per 1 μg of the rhCD4-Fc by the LAL method.
• Storage: Store at -20℃ in lyophilized state after receipt. For long term storage, upon reconstitution rhCD4-Fc should be aliquot and store at -20°C or -80°C. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: CD4 CD4 molecule [ Homo sapiens ]
• Official Symbol: CD4
• Synonyms: CD4; CD4 molecule; CD4mut; T-cell surface glycoprotein CD4; CD4 receptor; CD4 antigen (p55); T-cell surface antigen T4/Leu-3; CD4 (L3T4) ;T Cell Surface Antigen T4/Leu3; T Cell Surface Glycoprotein CD4; W3/25; W3/25 antigen; CD4 Antigen; CD4 Receptor ;CD4_HUMAN ;Lymphocyte antigen CD4; MGC165891 ;OTTHUMP00000238897; T cell differentiation antigen L3T4
• Gene ID: 920
• mRNA Refseq: NM_000616
• Protein Refseq: NP_000607
• UniProt ID: P01730
• Chromosome Location: 12p13.31
• Pathway: Adaptive Immune System; Alpha-defensins; Antigen processing and presentation