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Recombinant Human CD4 Protein, His & Avi-tagged

Cat.No. : CD4-24H
Product Overview : Biotinylated Human CD4, His Tag is expressed from human 293 cells (HEK293). It contains AA Lys 26 - Pro 396. This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag. The single lysine residue in the Avitag is enzymatically labeled with biotin.
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Description : T-cell surface glycoprotein CD4 is also known as T-cell surface antigen T4/Leu-3. CD4 contains three Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. CD4 is accessory protein for MHC class-II antigen/T-cell receptor interaction. CD4 induces the aggregation of lipid rafts. CD4 is a primary receptor used by HIV-1 to gain entry into host T cells. HIV infection leads to a progressive reduction of the number of T cells possessing CD4 receptors. Therefore, medical professionals refer to the CD4 count to decide when to begin treatment for HIV-infected patients.
Source : HEK293
Species : Human
Tag : His & Avi
Predicted N Terminal : Lys 26
Molecular Mass : The protein has a calculated MW of 45.0 kDa. The protein migrates as 55-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin : Less than 1.0 EU per μg by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
No activity loss is observed after storage at:
4-8 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Storage Buffer : Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.
Gene Name : CD4
Official Symbol : CD4 CD4 molecule [ Homo sapiens (human) ]
Synonyms : CD4; CD4mut; LEU3; CD4 molecule; T-cell surface glycoprotein CD4; CD4 antigen (p55); CD4 receptor; T-cell surface antigen T4/Leu-3
Gene ID : 920
mRNA Refseq : NM_000616
Protein Refseq : NP_000607
MIM : 186940
UniProt ID : P01730

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (3)

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What is the connection between CD4 and glycoprotein GP120? 11/09/2022

CD4 binds to glycoprotein GP120.

Where is CD4 primarily expressed? 02/26/2022

CD4 is mainly expressed in T cells and thymocytes.

Where is CD4 localized? 03/14/2021

CD4 is localized in the cell membrane.

Customer Reviews (3)

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Reviews
01/08/2031

    The CD4 proteins purchased from your company is suitable for ELISA.

    02/06/2023

      Protein products are put into experiments with good effect and reliable experimental results.

      01/22/2022

        The technical expert will follow up on the progress of my experiments and provide constructive advice on the problems that arise in my experiments.

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