Recombinant Human CD46 Protein, His-tagged

• Cat.No.: CD46-151H
• Product Overview: Recombinant Human CD46 molecule(CD46), transcript variant d(NM_153826), with a His tag, was expressed in human cells.

Specification

• Description: The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.
• Source: Human Cells
• Species: Human
• Tag: His
• Form: Purified protein formulated in a sterile solution of TBS buffer, pH7.146, without any preservatives.
• Molecular Mass: 33.83kD
• Endotoxin: Endotoxin level is < 0.1 ng/µg of protein (<1EU /µg)
• Purity: >90% by SDS-PAGE gel and Coomassie Blue staining
• Applications: Antigens, Western, ELISA and other in vitro binding or in vivo functional assays, and protein-protein interaction studies.

Gene Information

• Gene Name: CD46 CD46 molecule, complement regulatory protein [ Homo sapiens ]
• Official Symbol: CD46
• Synonyms: CD46; CD46 molecule, complement regulatory protein; antigen identified by monoclonal TRA 2 10 , CD46 antigen, complement regulatory protein , MCP, membrane cofactor protein (CD46, trophoblast lymphocyte cross reactive antigen) , MIC10; membrane cofactor protein; MGC26544; TLX; TRA2.10; measles virus receptor; complement membrane cofactor protein; trophoblast leucocyte common antigen; trophoblast leukocyte common antigen; CD46 antigen, complement regulatory protein; trophoblast-lymphocyte cross-reactive antigen; antigen identified by monoclonal TRA-2-10; membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen); MCP; AHUS2; MIC10
• Gene ID: 4179
• mRNA Refseq: NM_002389
• Protein Refseq: NP_002380
• MIM: 120920
• UniProt ID: P15529

Reviews

10/19/2022

The CD46 protein offers numerous advantages in trials and research studies, making it an excellent choice for scientists in need of reliable and high-quality experimental materials.

08/09/2019

With the CD46 protein and its accompanying technical assistance, I am confident that I can achieve successful outcomes for my research endeavors.

03/05/2019

Its unique properties make CD46 an invaluable tool for investigating cellular signaling pathways, protein-protein interactions, and membrane dynamics.

Q&As

How does CD46 protein interact with other immune system components?

CD46 protein interacts with complement regulatory proteins and immune cells to regulate immune responses and maintain homeostasis.

What are the potential side effects of targeting CD46 protein for therapy?

Potential side effects of targeting CD46 protein for therapy may include disturbances in immune regulation and increased susceptibility to infections.

How does the CD46 protein contribute to immune regulation?

CD46 protein regulates the activation of complement system and modulates T cell responses, contributing to immune regulation.

Can mutations in the CD46 gene lead to genetic disorders?

Mutations in the CD46 gene have been associated with genetic disorders such as atypical hemolytic uremic syndrome (aHUS) and other complement-related disorders.

Is CD46 protein involved in cancer progression or treatment resistance?

CD46 protein has been implicated in cancer progression and treatment resistance, particularly in certain types of leukemia and solid tumors.