CD46
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Official Full Name
CD46 molecule, complement regulatory protein
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Overview
The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010] -
Synonyms
CD46; CD46 molecule, complement regulatory protein; MCP; TLX; AHUS2; MIC10; TRA2.10; membrane cofactor protein; measles virus receptor; complement membrane cofactor protein; trophoblast leucocyte common antigen; trophoblast leukocyte common antigen; CD46 antigen, complement regulatory protein; trophoblast-lymphocyte cross-reactive antigen; antigen identified by monoclonal antibody TRA-2-10; membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen);
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cavia porcellus (Guinea pig)
- Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
- Cys35-Asp329
- Cys45-Gly344
- Guinea Pig
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Rat
- Rhesus Macaque
- Saguinus oedipus (Cotton-top tamarin)
- Sus scrofa (Pig)
- C-His
- CHO
- E.coli
- E.coli expression system
- HEK293
- Human Cell
- Human Cells
- In Vitro Cell Free System
- Mammalian cell
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Fc
- GST
- His
- Avi
- Non
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | CD46-0381H | Active Recombinant Human CD46 protein, hFc-tagged | Mammalian cell | Fc | 35-328aa |
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| Human | CD46-7592H | Recombinant Human CD46, His-tagged | E.coli | His | 35-313aa |
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| Human | CD46-0823H | Recombinant Human CD46 Protein, GST-Tagged | Wheat Germ | GST |
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| Human | CD46-3962H | Recombinant Human CD46 protein, His-tagged | HEK293 | His | Cys35-Asp328 | |
| Human | CD46-0822H | Recombinant Human CD46 Protein | Wheat Germ | Non |
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| Human | CD46-1964HCL | Recombinant Human CD46 cell lysate | Human Cell | Non |
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| Human | CD46-3963H | Active Recombinant Human CD46 Protein, Fc-tagged | CHO | Fc | 35-328 |
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| Human | CD46-151H | Recombinant Human CD46 Protein, His-tagged | Human Cells | His |
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| Human | CD46-2992HF | Recombinant Full Length Human CD46 Protein, GST-tagged | In Vitro Cell Free System | GST | 384 amino acids |
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| Human | CD46-031H | Recombinant Human CD46 Protein, hFc-tagged | HEK293 | Fc | Cys35-Asp343 |
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| Human | CD46-1506H | Recombinant Human CD46 Protein (Cys35-Asp325), N-His tagged | E.coli | His | Cys35-Asp325 |
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| Human | CD46-2984HF | Recombinant Full Length Human CD46 Protein | In Vitro Cell Free System | 94 amino acids |
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| Human | CD46-6463H | Recombinant Human CD46 protein, GST-tagged | E.coli | GST | 164-325aa |
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| Human | CD46-0253H | Recombinant Human CD46 protein, His-tagged | HEK293 | His | Met1-Asp328 |
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| Human | CD46-162H | Recombinant Human CD46 Protein, His-tagged | HEK293 | His | 392 |
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| Human | CD46-4521H | Recombinant Human CD46 Protein (Met1-Asp328), C-His tagged | Mammalian cells | His | Met1-Asp328 |
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| Human | CD46-1507H | Recombinant Human CD46 Protein (Val147-Lys285), N-His tagged | E.coli | His | Val147-Lys285 |
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| Mouse | Cd46-6755M | Recombinant Mouse Cd46 protein, His & GST-tagged | E.coli | His&GST | Asp157~Arg365 (Accession # O88174) |
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| Mouse | CD46-3093M | Recombinant Mouse CD46 Protein | Mammalian Cell | His |
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| Mouse | CD46-1463M | Recombinant Mouse CD46 Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi |
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| Mouse | CD46-394M | Recombinant Mouse CD46 Protein (45-329 aa), His-tagged | E.coli | His | 45-329 aa |
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| Mouse | CD46-1463M-B | Recombinant Mouse CD46 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rat | Cd46-6756R | Recombinant Rat Cd46 protein, His & GST-tagged | E.coli | His&GST | Met136~Val341 |
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| Rat | CD46-1254R | Recombinant Rat CD46 Protein | Mammalian Cell | His |
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| Rat | CD46-912R-B | Recombinant Rat CD46 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rat | CD46-912R | Recombinant Rat CD46 Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi |
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| Cavia porcellus (Guinea pig) | RFL6332CF | Recombinant Full Length Guinea Pig Membrane Cofactor Protein(Cd46) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (36-379) |
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| Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops) | RFL19632CF | Recombinant Full Length Chlorocebus Aethiops Membrane Cofactor Protein(Cd46) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (35-369) |
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| Cys35-Asp329 | CD46-1486C | Recombinant Cynomolgus CD46 protein, His-tagged | C-His | Cys35-Asp329 |
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| Cys45-Gly344 | CD46-1591C | Recombinant Canine CD46 protein, His-tagged | C-His | Cys45-Gly344 |
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| Guinea Pig | CD46-2331G | Recombinant Guinea Pig CD46 Protein (36-316 aa), His-tagged | E.coli | His | 36-316 aa |
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| Homo sapiens (Human) | RFL29938HF | Recombinant Full Length Human Membrane Cofactor Protein(Cd46) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (35-392) |
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| Mus musculus (Mouse) | RFL6707MF | Recombinant Full Length Mouse Membrane Cofactor Protein(Cd46) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (45-365) |
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| Rhesus Macaque | CD46-742R | Recombinant Rhesus monkey CD46 Protein, His-tagged | Mammalian Cell | His |
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| Rhesus Macaque | CD46-568R-B | Recombinant Rhesus Macaque CD46 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rhesus Macaque | CD46-568R | Recombinant Rhesus Macaque CD46 Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi |
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| Saguinus oedipus (Cotton-top tamarin) | RFL9177SF | Recombinant Full Length Saguinus Oedipus Membrane Cofactor Protein(Cd46) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (33-370) |
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| Sus scrofa (Pig) | RFL8067SF | Recombinant Full Length Pig Membrane Cofactor Protein(Cd46) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (45-363) |
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- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
CD46 involved in several pathways and played different roles in them. We selected most pathways CD46 participated on our site, such as Complement and coagulation cascades, Measles, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD46 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Complement and coagulation cascades | C1RA;PLAUR;SERPINA1D;C6;C1QC;CR2;C9;SERPINC1;C5 |
| Measles | SLAMF1;CD3E; CD3D;IFNB1;IFNGR1;OAS1;Fasl;FASLG;IL12B;IRF3 |
CD46 has several biochemical functions, for example, cadherin binding, complement binding, endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CD46 itself. We selected most functions CD46 had, and list some proteins which have the same functions with CD46. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cadherin binding | CTNNA1;CD46;FER;CTNNA3;PROM1;PTPRM;P2RX4;TBC1D2;CTNNB1 |
| complement binding | CFB;CD59;CD46;C8G;CR2;C8A |
| endopeptidase activity | CPS1;KLK1B26;TRAPPC12;PSMA1;PSMA6;PSMA6A;PSMB11;MMP9;ACE2 |
| enzyme inhibitor activity | APOV1;APBA3;UGT1A7;CSN2;GCHFR;OAZ1A;FRY;PDE6G;NOTCH1 |
| protein binding | COMMD9;SPI1B;RUFY3;TBRG1;RNF146;PVRL4;PHYHIPL;C19orf57;MCEE |
| receptor activity | CUBN;SLC20A2;NRP2;CADM1B;TEK;V1RA8;CNTNAP1;LILRA2;GFRA2A |
| virus receptor activity | CD209A;HLA-DRB1;F11R;HSPA1B;ANPEP;CXADR;TNFRSF14;GYPA;TNFRSF4 |
CD46 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD46 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD46.
JAG1; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate; C3; STK39; EBNA2; q8d1h5_yerpe; carA; toxA; toxB
Research Area
Related articles
- Reviews
- Q&As
Customer Reviews (3)
Write a reviewThe CD46 protein offers numerous advantages in trials and research studies, making it an excellent choice for scientists in need of reliable and high-quality experimental materials.
With the CD46 protein and its accompanying technical assistance, I am confident that I can achieve successful outcomes for my research endeavors.
Its unique properties make CD46 an invaluable tool for investigating cellular signaling pathways, protein-protein interactions, and membrane dynamics.
Q&As (5)
Ask a questionCD46 protein interacts with complement regulatory proteins and immune cells to regulate immune responses and maintain homeostasis.
Potential side effects of targeting CD46 protein for therapy may include disturbances in immune regulation and increased susceptibility to infections.
CD46 protein regulates the activation of complement system and modulates T cell responses, contributing to immune regulation.
Mutations in the CD46 gene have been associated with genetic disorders such as atypical hemolytic uremic syndrome (aHUS) and other complement-related disorders.
CD46 protein has been implicated in cancer progression and treatment resistance, particularly in certain types of leukemia and solid tumors.
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