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Official Full Name CD46 molecule, complement regulatory protein
Background The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]
Synonyms CD46; CD46 molecule, complement regulatory protein; MCP; TLX; AHUS2; MIC10; TRA2.10; membrane cofactor protein; measles virus receptor; complement membrane cofactor protein; trophoblast leucocyte common antigen; trophoblast leukocyte common antigen; CD46 antigen, complement regulatory protein; trophoblast-lymphocyte cross-reactive antigen; antigen identified by monoclonal antibody TRA-2-10; membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen);
    • Species :
    • Guinea Pig
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Human Cell
    • Human Cells
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • Fc
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CD46-151H Recombinant Human CD46 Protein, His-tagged Human Cells His
    Human CD46-0822H Recombinant Human CD46 Protein Wheat Germ N/A
    Human CD46-0823H Recombinant Human CD46 Protein, GST-Tagged Wheat Germ GST
    Human CD46-1964HCL Recombinant Human CD46 cell lysate Human Cell N/A
    Human CD46-3962H Recombinant Human CD46 protein, His-tagged HEK293 His
    Human CD46-3963H Recombinant Human CD46 Protein, Fc-tagged CHO Fc
    Human CD46-7592H Recombinant Human CD46, His-tagged E.coli His
    Mouse CD46-3093M Recombinant Mouse CD46 Protein Mammalian Cell His
    Mouse CD46-394M Recombinant Mouse CD46 Protein (45-329 aa), His-tagged E.coli His
    Mouse Cd46-6755M Recombinant Mouse Cd46 protein, His & GST-tagged E.coli His/GST
    Rat CD46-1254R Recombinant Rat CD46 Protein Mammalian Cell His
    Rat Cd46-6756R Recombinant Rat Cd46 protein, His & GST-tagged E.coli His/GST
    Rhesus Macaque CD46-742R Recombinant Rhesus monkey CD46 Protein, His-tagged Mammalian Cell His
    Guinea Pig CD46-2331G Recombinant Guinea Pig CD46 Protein (36-316 aa), His-tagged E.coli His

    cd46 involved in several pathways and played different roles in them. We selected most pathways cd46 participated on our site, such as Complement and coagulation cascades, Measles, which may be useful for your reference. Also, other proteins which involved in the same pathway with cd46 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Complement and coagulation cascades F5; F10; C1RA; F8; FGB; C4BPA; F2; CD59A; TFPI; CD59
    Measles IL4; RAB9B; FYN; RELA; TACR1; MAVS; Ifna11; IFNAR1; PIK3R3; IFNB1

    cd46 has several biochemical functions, for example, cadherin binding, complement binding, endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by cd46 itself. We selected most functions cd46 had, and list some proteins which have the same functions with cd46. You can find most of the proteins on our site.

    Function Related Protein
    cadherin binding CTNNAL1; Fert2; JUP; CTNNA3; PROM1; CD46; MMP24; JUPA; GNA13A; CTNNB1
    complement binding CD46; C8A; CR2; C8G; CFB; CD59
    endopeptidase activity HTRA3; AP1S2; KLK1B5; PSMA6A; PSMA7; PSEN1; PSMA2; SENP3A; PSMB9A; KLK1B1
    enzyme inhibitor activity SLN; NOTCH1; OAZ1A; KIAA1967; ARRB1; UGT1A7; CD46; UGT1A9; PLN; ATPIF1
    protein binding LEPR; PPP4R2; PTPRB; GRIN2B; PPP3R2; PEX13; BUC; GP5; NR1H3; NT5C2
    receptor activity V1RA8; PAQR5B; ATP6AP2; CALCR; LRP1; MED30; NR2C2; CLEC4E; AMHR2; GRIK3
    virus receptor activity PVRL2; SERPINB3; GPR172B; SCARB1; TNFRSF14; ITGB6; ITGB3; IDE; HYAL2; HAVCR1

    cd46 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cd46 here. Most of them are supplied by our site. Hope this information will be useful for your research of cd46.

    JAG1; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate; C3; STK39; EBNA2; q8d1h5_yerpe; carA; toxA; toxB

    Drager, C; Beer, M; et al. Porcine complement regulatory protein CD46 and heparan sulfates are the major factors for classical swine fever virus attachment in vitro. ARCHIVES OF VIROLOGY 160:739-746(2015).
    Scambi, C; Ugolini, S; et al. The Local Complement Activation on Vascular Bed of Patients with Systemic Sclerosis: A Hypothesis-Generating Study. PLOS ONE 10:-(2015).

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