CD46

  • Official Full Name

    CD46 molecule, complement regulatory protein

  • Overview

    The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]
  • Synonyms

    CD46; CD46 molecule, complement regulatory protein; MCP; TLX; AHUS2; MIC10; TRA2.10; membrane cofactor protein; measles virus receptor; complement membrane cofactor protein; trophoblast leucocyte common antigen; trophoblast leukocyte common antigen; CD46 antigen, complement regulatory protein; trophoblast-lymphocyte cross-reactive antigen; antigen identified by monoclonal antibody TRA-2-10; membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cavia porcellus (Guinea pig)
  • Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
  • Guinea Pig
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rhesus Macaque
  • Saguinus oedipus (Cotton-top tamarin)
  • Sus scrofa (Pig)
  • CHO
  • E.coli
  • E.coli expression system
  • HEK293
  • Human Cell
  • Human Cells
  • In Vitro Cell Free System
  • Mammalian cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Fc
  • GST
  • hFc
  • His (Fc)
  • Avi
  • His|GST
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CD46-0381H Active Recombinant Human CD46 protein, hFc-tagged Mammalian cell hFc 35-328aa
Human CD46-7592H Recombinant Human CD46, His-tagged E.coli His 35-313aa
Human CD46-0823H Recombinant Human CD46 Protein, GST-Tagged Wheat Germ GST
Human CD46-3962H Recombinant Human CD46 protein, His-tagged HEK293 His Cys35-Asp328
Human CD46-0822H Recombinant Human CD46 Protein Wheat Germ N/A
Human CD46-1964HCL Recombinant Human CD46 cell lysate Human Cell N/A
Human CD46-3963H Active Recombinant Human CD46 Protein, Fc-tagged CHO Fc 35-328
Human CD46-151H Recombinant Human CD46 Protein, His-tagged Human Cells His
Human CD46-2992HF Recombinant Full Length Human CD46 Protein, GST-tagged In Vitro Cell Free System GST 384 amino acids
Human CD46-031H Recombinant Human CD46 Protein, hFc-tagged HEK293 hFc Cys35-Asp343
Human CD46-1506H Recombinant Human CD46 Protein (Cys35-Asp325), N-His tagged E.coli N-His Cys35-Asp325
Human CD46-2984HF Recombinant Full Length Human CD46 Protein In Vitro Cell Free System 94 amino acids
Human CD46-6463H Recombinant Human CD46 protein, GST-tagged E.coli N-GST 164-325aa
Human CD46-0253H Recombinant Human CD46 protein, His-tagged HEK293 His Met1-Asp328
Human CD46-162H Recombinant Human CD46 Protein, His-tagged HEK293 His 392
Human CD46-4521H Recombinant Human CD46 Protein (Met1-Asp328), C-His tagged Mammalian cells C-His Met1-Asp328
Human CD46-1507H Recombinant Human CD46 Protein (Val147-Lys285), N-His tagged E.coli N-His Val147-Lys285
Mouse Cd46-6755M Recombinant Mouse Cd46 protein, His & GST-tagged E.coli His/GST Asp157~Arg365 (Accession # O88174)
Mouse CD46-3093M Recombinant Mouse CD46 Protein Mammalian Cell His
Mouse CD46-1463M Recombinant Mouse CD46 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CD46-394M Recombinant Mouse CD46 Protein (45-329 aa), His-tagged E.coli His 45-329 aa
Mouse CD46-1463M-B Recombinant Mouse CD46 Protein Pre-coupled Magnetic Beads HEK293
Rat Cd46-6756R Recombinant Rat Cd46 protein, His & GST-tagged E.coli His/GST Met136~Val341
Rat CD46-1254R Recombinant Rat CD46 Protein Mammalian Cell His
Rat CD46-912R-B Recombinant Rat CD46 Protein Pre-coupled Magnetic Beads HEK293
Rat CD46-912R Recombinant Rat CD46 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cavia porcellus (Guinea pig) RFL6332CF Recombinant Full Length Guinea Pig Membrane Cofactor Protein(Cd46) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (36-379)
Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops) RFL19632CF Recombinant Full Length Chlorocebus Aethiops Membrane Cofactor Protein(Cd46) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (35-369)
Guinea Pig CD46-2331G Recombinant Guinea Pig CD46 Protein (36-316 aa), His-tagged E.coli His 36-316 aa
Homo sapiens (Human) RFL29938HF Recombinant Full Length Human Membrane Cofactor Protein(Cd46) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (35-392)
Mus musculus (Mouse) RFL6707MF Recombinant Full Length Mouse Membrane Cofactor Protein(Cd46) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (45-365)
Rhesus Macaque CD46-742R Recombinant Rhesus monkey CD46 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CD46-568R-B Recombinant Rhesus Macaque CD46 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CD46-568R Recombinant Rhesus Macaque CD46 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Saguinus oedipus (Cotton-top tamarin) RFL9177SF Recombinant Full Length Saguinus Oedipus Membrane Cofactor Protein(Cd46) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (33-370)
Sus scrofa (Pig) RFL8067SF Recombinant Full Length Pig Membrane Cofactor Protein(Cd46) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (45-363)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CD46 involved in several pathways and played different roles in them. We selected most pathways CD46 participated on our site, such as Complement and coagulation cascades, Measles, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD46 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Complement and coagulation cascadesSERPING1;Serpina1c;F2R;CR1;F5;C9;PLAUR;MASP2;C7
MeaslesIL12B;IL13;IFNA8;TNFRSF10A;TP73;STAT2;FCGR2B;IFNA16;OAS1

CD46 has several biochemical functions, for example, cadherin binding, complement binding, endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CD46 itself. We selected most functions CD46 had, and list some proteins which have the same functions with CD46. You can find most of the proteins on our site.

Function Related Protein
cadherin bindingCTNNB1;NUMB;OLFM4;P2RX4;MMP24;CDK5R1;AKAP5;CTNNA3;CD2AP
complement bindingCD59;CFB;CR2;C8G;CD46;C8A
endopeptidase activityKLK1B11;PSMA4;NAPSA;KLK1B16;SENP3B;PSEN2;ACE;ADAM10;PSMB8F
enzyme inhibitor activityANGPTL3;UGT1A9;TXNIP;OAZ2A;CD46;PLN;PDE6G;APOV1;OAZ2B
protein bindingSRPK1;MTMR2;HOMER3;PIAS3;RBP5;ECE2;SDC4;TBRG1;KIF14
receptor activityVMN1R44;VMN1R43;RAMP3;CD1D;VMN1R49;GRIA3A;BTLA;CADM4;PAQR5
virus receptor activityTNFRSF4;CXCR4;SLC10A1;GYPA;SIVA1;SLC20A2;LAMP1;CLEC5A;CXADR

CD46 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD46 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD46.

JAG1; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate; C3; STK39; EBNA2; q8d1h5_yerpe; carA; toxA; toxB

Research Area

Related articles

Drager, C; Beer, M; et al. Porcine complement regulatory protein CD46 and heparan sulfates are the major factors for classical swine fever virus attachment in vitro. ARCHIVES OF VIROLOGY 160:739-746(2015).
Scambi, C; Ugolini, S; et al. The Local Complement Activation on Vascular Bed of Patients with Systemic Sclerosis: A Hypothesis-Generating Study. PLOS ONE 10:-(2015).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
How does CD46 protein interact with other immune system components? 08/20/2021

CD46 protein interacts with complement regulatory proteins and immune cells to regulate immune responses and maintain homeostasis.

What are the potential side effects of targeting CD46 protein for therapy? 01/05/2020

Potential side effects of targeting CD46 protein for therapy may include disturbances in immune regulation and increased susceptibility to infections.

How does the CD46 protein contribute to immune regulation? 08/11/2018

CD46 protein regulates the activation of complement system and modulates T cell responses, contributing to immune regulation.

Can mutations in the CD46 gene lead to genetic disorders? 09/22/2017

Mutations in the CD46 gene have been associated with genetic disorders such as atypical hemolytic uremic syndrome (aHUS) and other complement-related disorders.

Is CD46 protein involved in cancer progression or treatment resistance? 08/07/2016

CD46 protein has been implicated in cancer progression and treatment resistance, particularly in certain types of leukemia and solid tumors.

Customer Reviews (3)

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Reviews
10/19/2022

    The CD46 protein offers numerous advantages in trials and research studies, making it an excellent choice for scientists in need of reliable and high-quality experimental materials.

    08/09/2019

      With the CD46 protein and its accompanying technical assistance, I am confident that I can achieve successful outcomes for my research endeavors.

      03/05/2019

        Its unique properties make CD46 an invaluable tool for investigating cellular signaling pathways, protein-protein interactions, and membrane dynamics.

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