Active Recombinant Human CD6 Protein, hIgG/His-tagged

• Cat.No.: CD6-05H
• Product Overview: Recombinant human CD6 protein (18-402aa), fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Specification

• Description: This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis. Multiple transcript variants encoding different isoforms have been found for this gene.
• Source: Insect cells
• Species: Human
• Tag: hIgG/His
• Form: Liquid
• Bio-activity: Measured by the ability of the immobilized protein to support the adhesion of Jurkat human acute T cell leukemia cells. When cells are added to human CD6 coated plates 10 μg/mL. This effect is more to 50 %.
• Molecular Mass: 68.3 kDa
• AA Sequence: HPSPAPPDQLNTSSAESELWEPGER LPVRLTNGSSSCSGTVEVRLEASWE PACGALWDSRAAEAVCRALGCGGAE AASQLAPPTPELPPPPAAGNTSVAA NATLAGAPALLCSGAEWRLCEVVEH ACRSDGRRARVTCAENRALRLVDGG GACAGRVEMLEHGEWGSVCDDTWDL EDAHVVCRQLGCGWAVQALPGLHFT PGRGPIHRDQVNCSGAEAYLWDCPG LPGQHYCGHKEDAGAVCSEHQSWRL TGGADRCEGQVEVHFRGVWNTVCDS EWYPSEAKVLCQSLGCGTAVERPKG LPHSLSGRMYYSCNGEELTLSNCSW RFNNSNLCSQSLAARVLCSASRSLH NLSTPEVPASVQTVTIESSVTVKIE NKESRELMLL
• Endotoxin: < 1 EU/μg of protein (determined by LAL method)
• Purity: 90% by SDS - PAGE
• Applications: SDS-PAGE, Bioactivity
• Storage: Can be stored at +2 to +8 centigrade for 1 week. For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
• Concentration: 0.5 mg/mL
• Storage Buffer: In Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Gene Information

• Gene Name: CD6 CD6 molecule [ Homo sapiens (human) ]
• Official Symbol: CD6
• Synonyms: CD6; CD6 molecule; TP120; T-cell differentiation antigen CD6; CD6 antigen; T12
• Gene ID: 923
• mRNA Refseq: NM_006725
• Protein Refseq: NP_006716
• MIM: 186720
• UniProt ID: P30203