Recombinant Human CD80 protein, Fc-tagged (HPLC-verified)
Cat.No. : | CD80-55H |
Product Overview : | Recombinant Human CD80 protein (Val35-Asn242)(HPLC-verified), fused to human IgG1 Fc tag at C-terminus, was expressed in human 293 cells (HEK293). |
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Description : | B71 and B72, together with their receptors CD28 and CTLA4, constitute one of the dominant co-stimulatory pathways that regulate T and Bcell responses. Although both CTLA4 and CD28 can bind to the same ligands, CTLA4 binds to B71 and B72 with a 20-100 fold higher affinity than CD28 and is involved in the downregulation of the immune response. B-lymphocyte activation antigen B7-1 (referred to as B7) also known as cluster of Differentiation 80 (CD80), is a member of cell surface immunoglobulin superfamily and is expressed on activated B cells, activated T cells, macrophages and dendritic cells. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD80 works in tandem with CD86 to prime T cells. CD80 plays a role in induction of innate immune responses by activating NF-κB-signaling pathway in macrophages. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas. |
Source : | HEK293 |
Species : | Human |
Tag : | Fc |
Form : | Lyophilized from 0.22 um filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 50.0 kDa. The protein migrates as 65-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein length : | 208 |
Endotoxin : | Less than 1.0 EU per ug by the LAL method. |
Purity : | >95% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 centigrade to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | CD80 |
Official Symbol : | CD80 |
Synonyms : | CD80; CD80 molecule; CD28LG, CD28LG1, CD80 antigen (CD28 antigen ligand 1, B7 1 antigen) , CD80 molecule; T-lymphocyte activation antigen CD80; B lymphocyte activation antigen B7; B7 1; B7.1; activation B7-1 antigen; costimulatory factor CD80; CTLA-4 counter-receptor B7.1; B-lymphocyte activation antigen B7; costimulatory molecule variant IgV-CD80; CD80 antigen (CD28 antigen ligand 1, B7-1 antigen); B7; BB1; B7-1; LAB7; CD28LG; CD28LG1 |
Gene ID : | 941 |
mRNA Refseq : | NM_005191 |
Protein Refseq : | NP_005182 |
MIM : | 112203 |
UniProt ID : | P33681 |
Products Types
◆ Recombinant Protein | ||
CD80-547H | Recombinant Human CD80 Protein, His (Fc)-Avi-tagged | +Inquiry |
Cd80-848M | Recombinant Mouse Cd80 Protein, MYC/DDK-tagged | +Inquiry |
Cd80-36M | Recombinant Mouse CD80 Protein (ECD), Fc-His-tagged(C-ter) | +Inquiry |
CD80-0864H | Recombinant Human CD80 Protein, GST-Tagged | +Inquiry |
CD80-1376H | Acitve Recombinant Human CD80 protein(Met1-Asn242), His&Avi-tagged, Biotinylated | +Inquiry |
◆ Lysates | ||
CD80-1767MCL | Recombinant Mouse CD80 cell lysate | +Inquiry |
CD80-948CCL | Recombinant Cynomolgus CD80 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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