Active Recombinant Human CD86 Protein, Fc & Avi-tagged, Biotinylated
Cat.No. : | CD86-585H |
Product Overview : | Biotinylated Recombinant Human CD86 Protein (Leu 26 - Pro 247) (AAH40261), fused with a human IgG1 Fc tag at the C-terminus, followed by a Avi tag, was expressed in HEK293. |
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Source : | HEK293 |
Species : | Human |
Tag : | Fc & Avi |
Predicted N Terminal : | Leu 26 |
Form : | Lyophilized from sterile 50 mM tris, 100 mM glycine, pH7.5, 10% trehalose. |
Bio-activity : | Measured by its binding ability in a functional ELISA. Immobilized Human CTLA-4, Fc Tag at 5μg/mL (100 μL/well) can bind Biotinylated Human B7-2, Fc Tag with a linear range of 19-156 ng/mL. |
Molecular Mass : | Recombinant Human CD86 Protein has a calculated MW of 53.8 kDa. As a result of glycosylation, The protein migrates as 66-100 kDa under reducing (R) condition and 120-140 kDa under non-reducing (NR) condition on SDS-PAGE gel. |
Protein length : | Leu 26 - Pro 247 |
Endotoxin : | Less than 1.0 EU per μg by the LAL method. |
Purity : | >95% as determined by SDS-PAGE. |
Stability : | Samples are stable for up to twelve months from date of receipt at -70ºC. |
Storage : | Store it under sterile conditions at -20ºC~-70ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | CD86 CD86 molecule [ Homo sapiens ] |
Official Symbol : | CD86 |
Synonyms : | CD86; CD86 molecule; CD28LG2, CD86 antigen (CD28 antigen ligand 2, B7 2 antigen); T-lymphocyte activation antigen CD86; B lymphocyte antigen B7 2; B7 2; B7.2; BU63; FUN-1; CTLA-4 counter-receptor B7.2; B-lymphocyte activation antigen B7-2; CD86 antigen (CD28 antigen ligand 2, B7-2 antigen); B70; B7-2; LAB72; CD28LG2; MGC34413; |
Gene ID : | 942 |
mRNA Refseq : | NM_001206924 |
Protein Refseq : | NP_001193853 |
MIM : | 601020 |
UniProt ID : | P42081 |
Chromosome Location : | 3q21 |
Pathway : | Adaptive Immune System, organism-specific biosystem; Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; CD28 co-stimulation, organism-specific biosystem; CD28 dependent PI3K/Akt signaling, organism-specific biosystem; |
Function : | coreceptor activity; protein binding; receptor activity; |
Products Types
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◆ Lysates | ||
CD86-1971RCL | Recombinant Rat CD86 cell lysate | +Inquiry |
CD86-2619HCL | Recombinant Human CD86 cell lysate | +Inquiry |
CD86-1013CCL | Recombinant Cynomolgus CD86 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, several clinical trials are investigating the efficacy of CD86 inhibitors in various diseases, including autoimmune disorders and certain cancers.
In transplantation, CD86 blockade is investigated as a potential strategy to modulate the immune response and prevent graft rejection by inhibiting excessive T cell activation.
CD86 signaling is involved in the differentiation of T helper cells. Modulating CD86 levels may influence the balance between Th1 and Th2 responses, which is relevant in various immune-mediated diseases.
There is emerging evidence suggesting that CD86 expression levels may have prognostic value in certain diseases, guiding clinicians in predicting disease outcomes.
CD86 signaling is involved in the development and function of regulatory T cells, which play a crucial role in maintaining immune tolerance and preventing autoimmune reactions.
Customer Reviews (3)
Write a reviewWith the CD86 protein's high-quality composition and reliability, researchers can confidently proceed with their studies, knowing that they have access to a protein that consistently delivers accurate results.
Its high purity and stability ensure reliable and reproducible results, which are paramount for achieving meaningful scientific outcomes.
The CD86 protein is renowned for its outstanding quality, making it an optimal choice to fulfill the requirements of my experimental investigations.
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