Recombinant Human CDC42 Binding Protein Kinase Beta, GST-His-tagged

• Cat.No.: CDC42BPB-369H
• Product Overview: Recombinanthuman CDC42BPB containing amino acids M1-H472, N-terminally fused toGST-HIS6-Thrombin cleavage site.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST&His
• Protein Length: 1-472 a.a.
• Description: This geneencodes a member of the serine/threonine protein kinase family. The encodedprotein contains a Cdc42/Rac-binding p21 binding domain resembling that ofPAK kinase. The kinase domain of this protein is most closely related to thatof myotonic dystrophy kinase-related ROK. Studies of the similar gene in ratsuggested that this kinase may act as a downstream effector of Cdc42 incytoskeletal reorganization.
• Form: Liquid in50 mM Tris-HCl, pH 8.0 + 100 mM NaCl + 5 mM DTT + 4 mM reduced glutathione +20% glycerol.
• Molecular Weight: 84.4 kDa
• Purity: Affinitypurified using GSH-agarose.
• Specific Activity: 14 pmol/ugx min
• Storage: Store in working aliquots at -80°C.Avoid repeated freeze-thaw cycles.
• OfficialSymbol: CDC42BPB

Gene Information

• Gene Name: CDC42BPBCDC42 binding protein kinase beta (DMPK-like) [ Homo sapiens ]
• Synonyms: CDC42BPB;CDC42 binding protein kinase beta (DMPK-like); MRCKB; FLJ37601;FLJ44730; KIAA1124; DKFZp686H1431; CDC42-binding protein kinase beta(DMPK-like); Serine/threonine-proteinkinase MRCK beta; EC 2.7.11.1; CDC42-binding protein kinasebeta; CDC42BP-beta; DMPK-like beta; Myotonic dystrophy kinase-related CDC42-bindingkinase beta; MRCKbeta;myotonic dystrophy protein kinase-like beta; EC 2.7.11
• Gene ID: 9578
• mRNA Refseq: NM_006035
• Protein Refseq: NP_006026
• MIM: 614062
• UniProt ID: Q9Y5S2
• Chromosome Location: 14q32.3
• Function: proteinkinase binding; ATP binding; magnesium ion binding; nucleotidebinding; protein serine/threoninekinase activity; small GTPase regulator activity; Rho GTPase binding