| Description : |
This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Mapped to a previously identified cluster of cadherin genes on chromosome 16q22.1, the gene localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development. Alternatively spliced transcript variants encoding distinct isoforms have been identified. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
89.92 kDa |
| AA Sequence : |
MVPAWLWLLCVSVPQALPKAQPAEL SVEVPENYGGNFPLYLTKLPLPREG AEGQIVLSGDSGKATEGPFAMDPDS GFLLVTRALDREEQAEYQLQVTLEM QDGHVLWGPQPVLVHVKDENDQVPH FSQAIYRARLSRGTRPGIPFLFLEA SDRDEPGTANSDLRFHILSQAPAQP SPDMFQLEPRLGALALSPKGSTSLD HALERTYQLLVQVKDMGDQASGHQA TATVEVSIIESTWVSLEPIHLAENL KVLYPHHMAQVHWSGGDVHYHLESH PPGPFEVNAEGNLYVTRELDREAQA EYLLQVRAQNSHGEDYAAPLELHVL VMDENDNVPICPPRDPTVSIPELSP PGTEVTRLSAEDADAPGSPNSHVVY QLLSPEPEDGVEGRAFQVDPTSGSV TLGVLPLRAGQNILLLVLAMDLAGA EGGFSSTCEVEVAVTDINDHAPEFI TSQIGPISLPEDVEPGTLVAMLTAI DADLEPAFRLMDFAIERGDTEGTFG LDWEPDSGHVRLRLCKNLSYEAAPS HEVVVVVQSVAKLVGPGPGPGATAT VTVLVERVMPPPKLDQESYEASVPI SAPAGSFLLTIQPSDPISRTLRFSL VNDSEGWLCIEKFSGEVHTAQSLQG AQPGDTYTVLVEAQDTDEPRLSASA PLVIHFLKAPPAPALTLAPVPSQYL CTPRQDHGLIVSGPSKDPDLASGHG PYSFTLGPNPTVQRDWRLQTLNGSH AYLTLALHWVEPREHIIPVVVSHNA QMWQLLVRVIVCRCNVEGQCMRKVG RMKGMPTKLSAVGILVGTLVAIGIF LILIFTHWTMSRKKDPDQPADSVPL KATVTRTRPLEQKLISEEDLAANDI LDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
