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Recombinant Human CDH16 Protein, MYC/DDK-tagged

Cat.No. : CDH16-3151H
Product Overview : Recombinant Human CDH16 protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293.
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Description : This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Mapped to a previously identified cluster of cadherin genes on chromosome 16q22.1, the gene localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 87.9 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : CDH16 cadherin 16, KSP-cadherin [ Homo sapiens ]
Official Symbol : CDH16
Synonyms : KSP-cadherin; cadherin 16; kidney-specific cadherin; cadherin 16, KSP-cadherin
Gene ID : 1014
mRNA Refseq : NM_001204744
Protein Refseq : NP_001191673
MIM : 603118
UniProt ID : O75309

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Are there regulators related to the regulation of CDH16 protein expression? 12/09/2019

Yes, transcription factors and signaling pathways have been identified to be involved in the regulation of CDH16 protein expression, which regulate the expression level and function of CDH16 protein.

Is the expression level of CDH16 protein in tubular disease related to prognosis? 08/19/2019

Some studies suggest that the level of CDH16 protein expression in tubular disease may be prognostic. However, the specific mechanisms need to be further studied to confirm.

Are there genetic mutations associated with the CDH16 protein? 06/20/2019

Yes, genetic mutations associated with the CDH16 protein have been identified that may affect the expression level or function of the CDH16 protein.

Are there proteins that interact with the CDH16 protein? 06/01/2019

Yes, proteins that interact with the CDH16 protein have been found, including other cell adhesion molecules, signal transduction proteins, etc. These interactions may regulate the function and expression of the CDH16 protein.

Does there have any effects of post-translational modifications of CDH16 protein on its function? 05/22/2019

Post-translational modifications of the CDH16 protein can affect its function. For example, modifications such as phosphorylation and methylation can regulate the activity and stability of CDH16 protein.

What is the role of CDH16 protein in cell migration? 05/04/2019

The CDH16 protein plays an important role in cell migration. It is involved in regulating intercellular adhesion and the formation of extracellular matrix, and has a regulatory effect on cell migration and transfer.

Customer Reviews (3)

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Reviews
10/20/2022

    Have effective in drug delivery systems for drug loading and release.

    10/26/2019

      Can induce specific immune responses in immunotherapy, which has potential value for the treatment of diseases.

      07/24/2019

        It has good application potential in protein engineering and recombinant expression.

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