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Recombinant Human CDK5 Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : CDK5-4483H
Product Overview : CDK5 MS Standard C13 and N15-labeled recombinant protein (NP_004926) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
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  • Gene Information
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Description : This gene encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins. Unlike other members of the family, the protein encoded by this gene does not directly control cell cycle regulation. Instead the protein, which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons, functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization, endocytosis and exocytosis, and apoptosis. In humans, an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7. Alternative splicing results in multiple transcript variants.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 33.3 kDa
AA Sequence : MQKYEKLEKIGEGTYGTVFKAKNRE THEIVALKRVRLDDDDEGVPSSALR EICLLKELKHKNIVRLHDVLHSDKK LTLVFEFCDQDLKKYFDSCNGDLDP EIVKSFLFQLLKGLGFCHSRNVLHR DLKPQNLLINRNGELKLADFGLARA FGIPVRCYSAEVVTLWYRPPDVLFG AKLYSTSIDMWSAGCIFAELANAGR PLFPGNDVDDQLKRIFRLLGTPTEE QWPSMTKLPDYKPYPMYPATTSLVN VVPKLNATGRDLLQNLLKCNPVQRI SAEEALQHPYFSDFCPPTRTRPLEQ KLISEEDLAANDILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : CDK5 cyclin-dependent kinase 5 [ Homo sapiens (human) ]
Official Symbol : CDK5
Synonyms : CDK5; cyclin-dependent kinase 5; PSSALRE; TPKII catalytic subunit; protein kinase CDK5 splicing; cell division protein kinase 5; serine/threonine-protein kinase PSSALRE; tau protein kinase II catalytic subunit;
Gene ID : 1020
mRNA Refseq : NM_004935
Protein Refseq : NP_004926
MIM : 123831
UniProt ID : Q00535

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Is CDK5 derived from human fetal cell lines? 03/28/2023

The CDK5 is expressed from HEK293 host, which is a mammalian cells system.

In what other diseases or conditions might CDK5 be implicated? 03/17/2021

CDK5 has been studied in relation to psychiatric disorders like schizophrenia and bipolar disorder due to its involvement in neuronal function and synaptic plasticity.

Could CDK5 inhibition be beneficial in cancer treatment? 07/30/2019

Yes, some studies indicate that inhibiting CDK5 might suppress cancer cell proliferation and migration, showing promise as a target for cancer therapy.

How does CDK5 inhibition affect synaptic plasticity and memory? 03/30/2017

CDK5 inhibition can impact synaptic plasticity positively, potentially enhancing memory formation and cognition.

How does CDK5 function differently from other cyclin-dependent kinases? 11/10/2016

CDK5 is primarily active in post-mitotic neurons, unlike other CDKs that function during the cell cycle. Its activity is modulated by binding to non-cyclin proteins like p35 or p39.

Is there evidence supporting the use of CDK5 inhibitors in preclinical models of neurodegenerative diseases? 01/20/2016

Yes, preclinical studies have shown promising results in animal models, indicating the potential efficacy of CDK5 inhibitors in slowing disease progression.

Customer Reviews (3)

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Reviews
05/27/2019

    Its high quality greatly enhances the reliability and reproducibility of experimental data.

    01/06/2017

      Whether I need expertise in experimental optimization or troubleshooting, I can rely on the manufacturer's support to promptly address any concerns or queries.

      03/31/2016

        CDK5 protein is known for its versatility and functionality, enabling researchers to explore various biological processes and molecular interactions.

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