Active Recombinant Human CDK8 Protein, His-Tagged

• Cat.No.: CDK8-1039H
• Product Overview: Human CDK8 (NM_001260, 1 a.a. - 464 a.a.) and CCNC (NM_005190.3, 1 a.a. - 283 a.a.) recombinanat protein with His His tag expressed in Sf9 cells.

Specification

• Description: This gene encodes a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit, cyclin C, are components of the Mediator transcriptional regulatory complex, involved in both transcriptional activation and repression by phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II. This kinase regulates transcription by targeting the cyclin-dependent kinase 7 subunits of the general transcription initiation factor IIH, thus providing a link between the Mediator complex and the basal transcription machinery. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
• Source: Insect Cell
• Species: Human
• Tag: His
• Form: Liquid
• Bio-activity: 17 pmol/μg x min
• Molecular Mass: CDK8: 83.051, CCNC: kDa
• Applications: Functional Study
  SDS-PAGE
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing
• Concentration: 0.433 μg/μL
• Storage Buffer: In 50 mM Hepes, 100 mM NaCl, pH 7.5. (5 mM DTT, 20% glycerol)

Gene Information

• Gene Name: CDK8 cyclin-dependent kinase 8 [ Homo sapiens ]
• Official Symbol: CDK8
• Synonyms: CDK8; cyclin-dependent kinase 8; K35; protein kinase K35; CDK8 protein kinase; mediator complex subunit CDK8; cell division protein kinase 8; mediator of RNA polymerase II transcription subunit CDK8; MGC126074; MGC126075
• Gene ID: 1024
• mRNA Refseq: NM_001260
• Protein Refseq: NP_001251
• MIM: 603184
• UniProt ID: P49336