Recombinant Human CDK8 Protein, His-Tagged CDK8-1039H

Recombinant Human CDK8 Protein, His-Tagged


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Recombinant Human CDK8 Protein, His-Tagged

CDK8 Related Products

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Cat.No. : CDK8-1039H
Product Overview : Human CDK8 (NM_001260, 1 a.a. - 464 a.a.) and CCNC (NM_005190.3, 1 a.a. - 283 a.a.) recombinanat protein with His His tag expressed in Sf9 cells.
Description : This gene encodes a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit, cyclin C, are components of the Mediator transcriptional regulatory complex, involved in both transcriptional activation and repression by phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II. This kinase regulates transcription by targeting the cyclin-dependent kinase 7 subunits of the general transcription initiation factor IIH, thus providing a link between the Mediator complex and the basal transcription machinery. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
Source : Insect Cell
Species : Human
Tag : His
Form : Liquid
Bio-activity : 17 pmol/μg x min
Molecular Mass : CDK8: 83.051, CCNC: kDa
Applications : Functional Study
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing
Concentration : 0.433 μg/μL
Storage Buffer : In 50 mM Hepes, 100 mM NaCl, pH 7.5. (5 mM DTT, 20% glycerol)
Quality Control Testing :

2 μg/lane SDS-PAGE Stained with Coomassie Blue

Result of activity analysis :

Gene Name : CDK8 cyclin-dependent kinase 8 [ Homo sapiens ]
Official Symbol : CDK8
Synonyms : CDK8; cyclin-dependent kinase 8; K35; protein kinase K35; CDK8 protein kinase; mediator complex subunit CDK8; cell division protein kinase 8; mediator of RNA polymerase II transcription subunit CDK8; MGC126074; MGC126075;
Gene ID : 1024
mRNA Refseq : NM_001260
Protein Refseq : NP_001251
MIM : 603184
UniProt ID : P49336

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