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Recombinant Human CENPB Protein, GST-Tagged

Cat.No. : CENPB-1112H
Product Overview : Human CENPB full-length ORF (AAH53847.1, 1 a.a. - 599 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
  • Related Products
Description : This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies. [provided by RefSeq, Jul 2008]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 92.29 kDa
AA Sequence : MGPKRRQLTFREKSRIIQEVEENPD LRKGEIARRFNIPPSTLSTILKNKR AILASERKYGVASTCRKTNKLSPYD KLEGLLIAWFQQIRAAGLPVKGIIL KEKALRIAEELGMDDFTASNGWLDR FRRRHGVVSCSGVARARARNAAPRT PAAPASPAAVPSEGSGGSTTGWRAR EEQPPSVAEGYASQDVFSATETSLW YDFLPDQAAGLCGGDGRPRQATQRL SVLLCANADGSEKLPPLVAGKSAKP RAGQAGLPCDYTANSKGGVTTQALA KYLKALDTRMAAESRRVLLLAGRLA AQSLDTSGLRHVQLAFFPPGTVHPL ERGVVQQVKGHYRQAMLLKAMAALE GQDPSGLQLGLTEALHFVAAAWQAV EPSDIAACFREAGFGGGPNATITTS LKSEGEEEEEEEEEEEEEEGEGEEE EEEGEEEEEEGGEGEELGEEEEVEE EGDVDSDEEEEEDEESSSEGLEAED WAQGVVEAGGSFGAYGAQEEAQCPT LHFLEGGEDSDSDSEEEDDEEEDDE DEDDDDDEEDGDEVPVPSFGEAMAY FAMVKRYLTSFPIDDRVQSHILHLE HDLVHVTRKNHARQAGVRGLGHQS
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : CENPB centromere protein B, 80kDa [ Homo sapiens ]
Official Symbol : CENPB
Synonyms : CENPB; centromere protein B, 80kDa; centromere protein B (80kD); major centromere autoantigen B; CENP-B; centromere autoantigen B;
Gene ID : 1059
mRNA Refseq : NM_001810
Protein Refseq : NP_001801
MIM : 117140
UniProt ID : P07199

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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