Cat. No. : |
CFHR5-920H |
Description : |
The human complement factor H protein family consists of the complement and immune regulators factor H, the factor Hlike protein 1 and five factor H related proteins (FHR1 to 5). Members of this family are exclusively composed of individually folded protein domains, termed short consensus repeats (SCRs) or complement control modules. The genes of this family have been located in human chromosome 1q32, which is known as the regulator of complement activation (RCA) gene clusters. FHR5 has been identified initially as a universal component of complement deposits, and detected in glomerular immune deposit. The pattern of deposits is similar to other complement components, suggesting that FHR5 may play a role in complement activation and regulation. It is synthesized in the liver and consists of 9 SCRs. Its biological function is not understood fully. FHR5 exhibits similar characteristics as those of factor H in heparin binding, CRP binding, and lipoprotein association. Weak factor Idependent cofactor activity for C3b cleavage has also been observed. |
Source : |
Mammalian cells |
Purity : |
>90% as determined by SDS-PAGE |
PredictedN terminal : |
Glu 19 |
MolecularMass : |
Predicted molecular mass of this protein is 64 KDa. It migrates as an approximately 73 KDa band in SDS-PAGE under reducing conditions. |
Formulation : |
Lyophilized from a 0.2 μm filtered solution in Tris and NaCl. |
Endotoxin : |
<1.0 EU per 1 μg of the protein as determined by the LAL method. |
Reconstitution : |
Reconstitute at 100 μg/mL in sterile PBS. |
Activity : |
Measured by its ability to inhibit the binding of biotinylated Recombinant Human Complement Factor Hrelated 5/CFHR5 to immobilized Recombinant Human C-Reactive Protein/CRP. |
Storage : |
1 year from date of receipt, 20 to 70 °C as supplied. Avoid repeatedFreeze/thaw cycles. |
OfficialSymbol : |
CFHR5 |