Recombinant Human Chemokine (C-X-C Motif) Ligand 11, His-tagged

• Cat.No.: CXCL11-270H
• Product Overview: Recombinant human CXCL11 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.

Specification

• Species: Human
• Source: Human
• Tag: His
• Description: Chemokine (C-X-C motif) ligand 11 (CXCL11) is a small cytokine belonging to the CXC chemokine family that is also called Interferon-inducible T-cell alpha chemoattractant (I-TAC) and Interferon-gamma-inducible protein 9 (IP-9). CXCL11 is strongly induced by IFN-μ and IFN-μ, and weakly induced by IFN-μ. It is chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. It is highly expressed in peripheral blood leukocytes, pancreas and liver, with moderate levels in thymus, spleen and lung and low expression levels were in small intestine, placenta and prostate.
• Form: Liquid. In 10mM sodium citrate(pH 3.5), 20% glycerol, 2mM DTT
• Molecular Weight: 10.6kDa (94aa), confirmed by MALDI-TOF
• Purity: > 90% by SDS - PAGE
• Concentration: 1mg/ml (determined by Bradford assay)
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MFPMFKRGRC LCIGPGVKAV KVADIEKASI MYPSNNCDKI EVIITLKENK GQRCLNPKSK QARLIIKKVE RKNF
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Pathways: Cytokine-cytokine receptor interaction;Toll-like receptor signaling pathway.

Gene Information

• Gene Name: CXCL11 chemokine (C-X-C motif) ligand 11 [ Homo sapiens ]
• Official Symbol: CXCL11
• Synonyms: CXCL11; IP9; Beta-R1; H174; IP-9; b-R1; ITAC; I-TAC; SCYB11; SCYB9B; MGC102770; C-X-C motif chemokine 11 precursor;Human beta-R1 mRNA, partial cds; CXL11_HUMAN; chemokine (C-X-C motif) ligand 11; Interferon-gamma-inducible protein 9; Interferon-inducible T-cell alpha chemoattractant; Small-inducible cytokine B11; chemokine (C-X-C motif) ligand 11; small inducible cytokine B11; small inducible cytokine subfamily B (Cys-X-Cys), member 11; small inducible cytokine subfamily B (Cys-X-Cys), member
• Gene ID: 6373
• mRNA Refseq: NM_005409
• Protein Refseq: NP_005400
• MIM: 604852
• UniProt ID: O14625
• Chromosome Location: 4q21.2
• Function: chemokine activity