Recombinant Human CHMP4B Protein, MYC/DDK-tagged

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Recombinant Human CHMP4B Protein, MYC/DDK-tagged

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Cat.No. : CHMP4B-3237H
Product Overview : Recombinant Human CHMP4B protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293.
Description : This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominant posterior polar cataracts.
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 24.8 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : CHMP4B charged multivesicular body protein 4B [ Homo sapiens ]
Official Symbol : CHMP4B
Synonyms : C20orf178; CHMP4A; CTPP3; CTRCT31; dJ553F4.4; Shax1; SNF7; SNF7-2; Vps32-2; VPS32B
Gene ID : 128866
mRNA Refseq : NM_176812
Protein Refseq : NP_789782
MIM : 610897
UniProt ID : Q9H444

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