Recombinant Human CISH, GST-tagged

• Cat.No.: CISH-11255H
• Product Overview: Recombinant Human CISH protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: 1-258a.a.
• Description: The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: CISH cytokine inducible SH2-containing protein [ Homo sapiens ]
• Official Symbol: CISH
• Synonyms: CISH; cytokine inducible SH2-containing protein; cytokine-inducible SH2-containing protein; CIS; CIS 1; G18; SOCS; suppressor of cytokine signaling; cytokine-inducible inhibitor of signaling type 1B; CIS-1; BACTS2
• Gene ID: 1154
• mRNA Refseq: NM_013324
• Protein Refseq: NP_037456
• MIM: 602441
• UniProt ID: Q9NSE2
• Chromosome Location: 3p21.3
• Pathway: Cytokine Signaling in Immune system, organism-specific biosystem; ECS complex, organism-specific biosystem; ECS complex, conserved biosystem; EPO Receptor Signaling, organism-specific biosystem; Growth hormone receptor signaling, organism-specific biosystem; IL-2 Signaling Pathway, organism-specific biosystem; IL-3 Signaling Pathway, organism-specific biosystem
• Function: molecular_function