Recombinant Human CISH Protein, GST-tagged

• Cat.No.: CISH-1380H
• Product Overview: Human CISH full-length ORF ( AAH31590.1, 1 a.a. - 258 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 54.12 kDa
• AA Sequence: MVLCVQGPRPLLAVERTGQRPLWAP SLELPKPVMQPLPAGAFLEEVAEGT PAQTESEPKVLDPEEDLLCIAKTFS YLRESGWYWGSITASEARQHLQKMP EGTFLVRDSTHPSYLFTLSVKTTRG PTNVCIEYADSSFRLDSNCLSRPRI LAFPDVVSLVQHYVASCTADTRSDS PDPAPTPALPMPKEDAPSDPALPAP PPATAVHLKLVQPFVRRSSARSLQH LCRLVINRLVADVDCLPLPRRMAGY LRQYPFQL
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: CISH cytokine inducible SH2-containing protein [ Homo sapiens ]
• Official Symbol: CISH
• Synonyms: CISH; cytokine inducible SH2-containing protein; cytokine-inducible SH2-containing protein; CIS; CIS 1; G18; SOCS; suppressor of cytokine signaling; cytokine-inducible inhibitor of signaling type 1B; CIS-1; BACTS2
• Gene ID: 1154
• mRNA Refseq: NM_013324
• Protein Refseq: NP_037456
• MIM: 602441
• UniProt ID: Q9NSE2