Recombinant Human CLCNKB Protein, GST-tagged

• Cat.No.: CLCNKB-1423H
• Product Overview: Human CLCNKB full-length ORF ( AAH20873.1, 1 a.a. - 462 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene is a member of the family of voltage-gated chloride channels. Chloride channels have several functions, including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. This gene is expressed predominantly in the kidney and may be important for renal salt reabsorption. Mutations in this gene are associated with autosomal recessive Bartter syndrome type 3 (BS3). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 77 kDa
• AA Sequence: MEEFVGLREGSSGNPVTLQELWGPC PRIRRGIRGGLEWLKQKLFRLGEDW YFLMTLGVLMALVSCAMDLAVESVV RAHQWLYREIGDSHLLRYLSWTVYP VALVSFSSGFSQSITPSSGGSGIPE VKTMLAGVVLEDYLDIKNFGAKVVG LSCTLACGSTLFLGKVGPFVHLSVM MAAYLGRVRTTTIGEPENKSKPVYS ALATLVLASITYPPSAGRFLASRLS MKQHLDSLFDNHSWALMTQNSSPPW PEELDPQHLWWEWYHPRFTIFGTLA FFLVMKFWMLILATTIPMPAGYFMP IFVYGAAIGRLFGETLSFIFPEGIV AGGITNPIMPGGYALAGAAAFSGAV THTISTALLAFEVTGQIVHALPVLM AVLAANAIAQSCQPSFYDGTVIVKK LPYLPRILGRNIGSHRVRVEHFMNH SITTLAITLMNDEIGVHCHQGQAQM ASGVVWFPVRGS
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: CLCNKB chloride channel, voltage-sensitive Kb [ Homo sapiens ]
• Official Symbol: CLCNKB
• Synonyms: CLCNKB; chloride channel, voltage-sensitive Kb; chloride channel Kb; chloride channel protein ClC-Kb; hClC Kb; chloride channel, kidney, B; CLCKB; ClC-K2; ClC-Kb; MGC24087
• Gene ID: 1188
• mRNA Refseq: NM_000085
• Protein Refseq: NP_000076
• MIM: 602023
• UniProt ID: P51801