Recombinant Human CLK2 Protein, GST-tagged

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Recombinant Human CLK2 Protein, GST-tagged

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Cat.No. : CLK2-1493H
Product Overview : Human CLK2 (AAH53603.1, 1 a.a. - 499 a.a.) full-length recombinant protein with GST tag expressed in baculovirus infected Sf21 cells.
Description : This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of the spliceosomal complex, thereby influencing alternative transcript splicing. Chromosomal translocations have been characterized between this locus and the PAFAH1B3 (platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)) gene on chromosome 19, resulting in the production of a fusion protein. Note that this gene is distinct from the TELO2 gene (GeneID:9894), which shares the CLK2 alias, but encodes a protein that is involved in telomere length regulation. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Source : Insect Cells
Species : Human
Tag : GST
Form : Liquid
Bio-activity : The activity was measured by off-chip mobility shift assay. The enzyme was incubated with fluorescence-labeled substrate and Mg(or Mn)/ATP. The phosphorylated and unphosphorylated substrates were separated and detected by LabChip 3000. Substrate: DYRKtide-F. ATP: 100 uM.
Molecular Mass : 87 kDa
Purity : 69 % by SDS-PAGE/CBB staining
Applications : Functional Study
SDS-PAGE
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : In 50 mM Tris-HCl, 150 mM NaCl, pH 7.5 (0.1% CHAPS, 1 mM DTT, 10% glycerol)
Quality Control Testing: :

Loading 1 μg protein in SDS-PAGE

Result of activity analysis :

Gene Name : CLK2 CDC-like kinase 2 [ Homo sapiens ]
Official Symbol : CLK2
Synonyms : CLK2; CDC-like kinase 2; dual specificity protein kinase CLK2; clk2; CLK kinase; hCLK2; MGC61500;
Gene ID : 1196
mRNA Refseq : NM_003993
Protein Refseq : NP_003984
MIM : 602989
UniProt ID : P49760

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