| Description : |
This gene is a member of the calsyntenin family, a subset of the cadherin superfamily. The encoded transmembrane protein, also known as alcadein-alpha, is thought to bind to kinesin-1 motors to mediate the axonal anterograde transport of certain types of vesicle. Amyloid precursor protein (APP) is trafficked via these vesicles and so this protein is being investigated to see how it might contribute to the mechanisms underlying Alzheimer's disease. Alternative splicing results in multiple transcript variants. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
109.6 kDa |
| AA Sequence : |
MLRRPAPALAPAARLLLAGLLCGGG VWAARVNKHKPWLEPTYHGIVTEND NTVLLDPPLIALDKDAPLRFAESFE VTVTKEGEICGFKIHGQNVPFDAVV VDKSTGEGVIRSKEKLDCELQKDYS FTIQAYDCGKGPDGTNVKKSHKATV HIQVNDVNEYAPVFKEKSYKATVIE GKQYDSILRVEAVDADCSPQFSQIC SYEIITPDVPFTVDKDGYIKNTEKL NYGKEHQYKLTVTAYDCGKKRATED VLVKISIKPTCTPGWQGWNNRIEYE PGTGALAVFPNIHLETCDEPVASVQ ATVELETSHIGKGCDRDTYSEKSLH RLCGAAAGTAELLPSPSGSLNWTMG LPTDNGHDSDQVFEFNGTQAVRIPD GVVSVSPKEPFTISVWMRHGPFGRK KETILCSSDKTDMNRHHYSLYVHGC RLIFLFRQDPSEEKKYRPAEFHWKL NQVCDEEWHHYVLNVEFPSVTLYVD GTSHEPFSVTEDYPLHPSKIETQLV VGACWQEFSGVENDNETEPVTVASA GGDLHMTQFFRGNLAGLTLRSGKLA DKKVIDCLYTCKEGLDLQVLEDSGR GVQIQAHPSQLVLTLEGEDLGELDK AMQHISYLNSRQFPTPGIRRLKITS TIKCFNEATCISVPPVDGYVMVLQP EEPKISLSGVHHFARAASEFESSEG VFLFPELRIISTITREVEPEGDGAE DPTVQESLVSEEIVHDLDTCEVTVE GEELNHEQESLEVDMARLQQKGIEV SSSELGMTFTGVDTMASYEEVLHLL RYRNWHARSLLDRKFKLICSELNGR YISNEFKVEVNVIHTANPMEHANHM AAQPQFVHPEHRSFVDLSGHNLANP HPFAVVPSTATVVIVVCVSFLVFMI ILGVFRIRAAHRRTMRDQDTGKENE MDWDDSALTITVNPMETYEDQHSSE EEEEEEEEEESEDGEEEDDITSAES ESSEEEEGEQGDPQNATRQQQLEWD DSTLSYTRTRPLEQKLISEEDLAAN DILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
