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Recombinant Human CMPK1 protein

Cat.No.: CMPK1-46H
Product Overview: Recombinant Human CMPK1 was expressed in E. coli.
Description: UMP-CMP kinase plays a critical role in supplying cells with nucleotides by catalysing the phosphorylation of CMP, UMP and dCMP to their respective diphosphates. CMK plays also an important role in the activation of cytidine analogues, aracytidine and gemcitabine, a mainstay of leukaemia and lymphoma therapy. CMK has a remarkable ability of to phosphorylate L-nucleotides from their monophosphate to diphosphate forms as shown for β-L-2’3’-dideoxy-3’thiacytidine (L-SSdC, 3-TC or lamividune), an anti-HIV and anti-hepatitis B drug.
Source: E. coli
Species: Human
Form: 150mM KCl, 50mM Tris-Hcl, pH7,5, 2mM β-mercaptoethanol, 50% glycerol.
Bio-activity: ≥1 unit/mg protein.
Molecular Mass: 27kDa
Protein length: 228aa
Unit Definition: One unit of UMP-CMP kinase converts 1.0 µmole of UMP and ATP to UDP and ADP per minute at pH 7.6 at 25 centigrade, using a coupled enzyme system with PK/LDH.
Applications: CMK enzyme is a highly pure and active cloned human UMP-CMP Kinase which can be used:• to characterize a monophosphorylated nucleotide analogue as a potential substrate of CMK• to quantify UMP, CMP, dUMP or dCMP in a sample• to synthesize enzymatically the di-phosphate form of nucleotide analogue from its monophosphate form (e.g. dFdC-DP)
Storage: Store at–20 centigrade
Gene Name: CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic [ Homo sapiens ]
Official Symbol: CMPK1
Synonyms: CMPK1; cytidine monophosphate (UMP-CMP) kinase 1, cytosolic; CMPK, cytidylate kinase; UMP-CMP kinase; Cytidine monophosphate kinase; UMP CMP kinase; UMP CMPK; UMP/CMP kinase; cytidylate kinase; deoxycytidylate kinase; uridine monophosphate kinase; uridine monophosphate/cytidine monophosphate kinase; CMK; UMK; CMPK; UMPK; UMP-CMPK; RP11-511I2.1;
Gene ID: 51727
mRNA Refseq: NM_001136140
Protein Refseq: NP_001129612
MIM: 191710
UniProt ID: P30085
Chromosome Location: 1p34.1-p33
Pathway: Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of nucleotides, organism-specific biosystem; Pyrimidine metabolism, organism-specific biosystem; Pyrimidine metabolism, conserved biosystem; Pyrimidine ribonucleotide biosynthesis, UMP => UDP/UTP,CDP/CTP, organism-specific biosystem;
Function: ATP binding; cytidylate kinase activity; nucleotide binding; phosphotransferase activity, phosphate group as acceptor; transferase activity; uridine kinase activity;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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