Recombinant Human CNTF Protein CNTF-020H

Recombinant Human CNTF Protein


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Cat.No. : CNTF-020H Optional Service: Optional requirements on this protein
Product Overview : The mature recombinant human CNTF protein consists of 199 amino acids (2-200) without tag was expressed in E. coli.
Description : The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse.
Source : E. coli
Species : Human
Bio-activity : Fully biologically active when compared to standard. The ED50 as determined by the dose-dependant stimulation of TF-1 cells is less than 3.0 ng/mL.
Molecular Mass : 22.8 kDa
Product-Related Proteins : 2-200
Endotoxin : < 0.1 EU/μg of the protein as determined by the LAL method
Purity : > 95 % as determined by SDS-PAGE
Storage : At -80 centigrade. Avoid repeated freeze-thaw cycles.
Storage Buffer : PBS
Gene Name : CNTF ciliary neurotrophic factor [ Homo sapiens (human) ]
Official Symbol : CNTF
Synonyms : CNTF; ciliary neurotrophic factor; HCNTF; ciliary neurotrophic factor; Ciliary Neuronotrophic Factor
Gene ID : 1270
mRNA Refseq : NM_000614
Protein Refseq : NP_000605
MIM : 118945
UniProt ID : P26441
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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