Recombinant Human COBRA1 Protein, GST-tagged

• Cat.No.: COBRA1-1618H
• Product Overview: Human COBRA1 full-length ORF ( AAH11892, 1 a.a. - 475 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: NELFB is a subunit of negative elongation factor (NELF), which also includes NELFA (WHSC2; MIM 606026), either NELFC or NELFD (TH1L; MIM 605297), and NELFE (RDBP; MIM 154040). NELF acts with DRB sensitivity-inducing factor (DSIF), a heterodimer of SPT4 (SUPT4H1; MIM 603555) and SPT5 (SUPT5H; MIM 602102), to cause transcriptional pausing of RNA polymerase II (see MIM 180660) (Narita et al., 2003 [PubMed 12612062]).[supplied by OMIM, Mar 2008]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 77.99 kDa
• AA Sequence: MPSLQPVVMCVMKHLPKVPEKKLKL VMADKELYRACAVEVKRQIWQDNQA LFGDEVSPLLKQYILEKESALFSTE LSVLHNFFSPSPKTRRQGEVVQRLT RMVGKNVKLYDMVLQFLRTLFLRTR NVHYCTLRAELLMSLHDLDVGEICT VDPCHKFTWCLDACIRERFVDSKRA RELQGFLDGVKKGQEQVLGDLSMIL CDPFAINTLALSTVRHLQELVGQET LPRDSPDLLLLLRLLALGQGAWDMI DSQVFKEPKMEVELITRFLPMLMSF LVDDYTFNVDQKLPAEEKAPVSYPN TLPESFTKFLQEQRMACEVGLYYVL HITKQRNKNALLRLLPGLVETFGDL AFGDIFLHLLTGNLALLADEFALED FCSSLFDGFFLTASPRKENVHRHAL RLLIHLHPRVAPSKLEALQKALEPT GQSGEAVKELYSQLGEKLEQLDHRK PSPAQAAETPALELPLPSVPAPAPL
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: COBRA1 cofactor of BRCA1 [ Homo sapiens ]
• Official Symbol: COBRA1
• Synonyms: COBRA1; cofactor of BRCA1; negative elongation factor B; KIAA1182; NELF B; negative elongation factor protein B; NELFB; NELF-B; RP13-122B23.3; DKFZp586B0519
• Gene ID: 25920
• mRNA Refseq: NM_015456
• Protein Refseq: NP_056271
• MIM: 611180
• UniProt ID: Q8WX92