Recombinant Human COIL

• Cat.No.: COIL-26172TH
• Product Overview: Recombinant fragment of Human Coilin with a proprietary tag: predicted molecular weight 36.52 kDa.

Specification

• Description: The protein encoded by this gene is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14.
• Protein length: 99 amino acids
• Molecular Weight: 36.520kDa inclusive of tags
• Source: Wheat germ
• Tissue specificity: Found in all the cell types examined.
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.79% Tris HCl, 0.31% Glutathione
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: IAFKLLELTSSYSPDVSDYKEGRIL SHNPETQQVDIEILSSLPALREPGK FDLVYHNENGAEVVEYAVTQESKIT VFWKELIDPRLIIESPSNTSSTEP
• Sequence Similarities: Belongs to the coilin family.

Gene Information

• Gene Name: COIL coilin [ Homo sapiens ]
• Official Symbol: COIL
• Synonyms: COIL; coilin; CLN80; p80 coilin
• Gene ID: 8161
• mRNA Refseq: NM_004645
• Protein Refseq: NP_004636
• MIM: 600272
• Uniprot ID: P38432
• Chromosome Location: 17q22-q23
• Function: disulfide oxidoreductase activity; identical protein binding; protein C-terminus binding; protein binding