Recombinant Human COMT Protein, Myc/DDK-tagged, C13 and N15-labeled

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Recombinant Human COMT Protein, Myc/DDK-tagged, C13 and N15-labeled

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Cat.No. : COMT-4987H
Product Overview : COMT MS Standard C13 and N15-labeled recombinant protein (NP_009294) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
Description : Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 24.9 kDa
AA Sequence : MGDTKEQRIL NHVLQHAEPG NAQSVLEAID TYCEQKEWAM NVGDKKGKIV DAVIQEHQPS VLLELGAYCG YSAVRMARLL SPGARLITIE INPDCAAITQ RMVDFAGVKD KVTLVVGASQ DIIPQLKKKY DVDTLDMVFL DHWKDRYLPD TLLLEECGLL RKGTVLLADN VICPGAPDFL AHVRGSSCFE CTHYQSFLEY REVVDGLEKA IYKGPGSEAG PTRTRPLEQK LISEEDLAAN DILDYKDDDD KV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
SDS-PAGE :

Gene Name : COMT catechol-O-methyltransferase [ Homo sapiens (human) ]
Official Symbol : COMT
Synonyms : COMT; catechol-O-methyltransferase; catechol O-methyltransferase;
Gene ID : 1312
mRNA Refseq : NM_007310
Protein Refseq : NP_009294
MIM : 116790
UniProt ID : P21964

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