| Description : |
This gene encodes a member of the coronin protein family. However, unlike other coronin proteins, it is not an actin-binding protein but rather functions as an F-actin regulator directing anterograde Golgi to endosome transport. The encoded protein has two tandem WD-40 domain repeats and localizes to the trans-Golgi network. The protein undergoes K33-linked polyubiquitination via an E3 ligase complex. It is thought to play an essential role in maintenance of Golgi apparatus morphology. Alternative splicing results in multiple transcripts variants; some of which form read-through transcripts with a neighboring gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
100.6 kDa |
| AA Sequence : |
MNRFRVSKFRHTEARPPRRESWISD IRAGTAPSCRNHIKSSCSLIAFNSD RPGVLGIVPLQGQGEDKRRVAHLGC HSDLVTDLDFSPFDDFLLATGSADR TVKLWRLPGPGQALPSAPGVVLGPE DLPVEVLQFHPTSDGILVSAAGTTV KVWDAAKQQPLTELAAHGDLVQSAV WSRDGALVGTACKDKQLRIFDPRTK PRASQSTQAHENSRDSRLAWMGTWE HLVSTGFNQMREREVKLWDTRFFSS ALASLTLDTSLGCLVPLLDPDSGLL VLAGKGERQLYCYEVVPQQPALSPV TQCVLESVLRGAALVPRQALAVMSC EVLRVLQLSDTAIVPIGYHVPRKAV EFHEDLFPDTAGCVPATDPHSWWAG DNQQVQKVSLNPACRPHPSFTSCLV PPAEPLPDTAQPAVMETPVGDADAS EGFSSPPSSLTSPSTPSSLGPSLSS TSGIGTSPSLRSLQSLLGPSSKFRH AQGTVLHRDSHITNLKGLNLTTPGE SDGFCANKLRVAVPLLSSGGQVAVL ELRKPGRLPDTALPTLQNGAAVTDL AWDPFDPHRLAVAGEDARIRLWRVP AEGLEEVLTTPETVLTGHTEKICSL RFHPLAANVLASSSYDLTVRIWDLQ AGADRLKLQGHQDQIFSLAWSPDGQ QLATVCKDGRVRVYRPRSGPEPLQE GPGPKGGRGARIVWVCDGRCLLVSG FDSQSERQLLLYEAEALAGGPLAVL GLDVAPSTLLPSYDPDTGLVLLTGK GDTRVFLYELLPESPFFLECNSFTS PDPHKGLVLLPKTECDVREVELMRC LRLRQSSLEPVAFRLPRVRKEFFQD DVFPDTAVIWEPVLSAEAWLQGANG QPWLLSLQPPDMSPVSQAPREAPAR RAPSSAQYLEEKSDQQKKEELLNAM VAKLGNREDPLPQDSFEGVDEDEWD SGPTRTRPLEQKLISEEDLAANDIL DYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
