Recombinant Human CPB2 protein, His-tagged

• Cat.No.: CPB2-606H
• Product Overview: Recombinant Human CPB2 aa. (Glu138~Val423 (Accession # Q96IY4)) fused with N-terminal His tag was produced in E. coli cells.

Specification

• Description: Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 34.5kDa
• Protein length: Glu138~Val423 (Accession # Q96IY4)
• Endotoxin: <1.0EU per 1µg (determined by the LAL method)
• Purity: >95%
• Characteristic: The isoelectric point is 8.5.
• Applications: SDS-PAGE; WB; ELISA; IP
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage buffer: Supplied as lyophilized form in PBS, pH7.4, containing 5% sucrose, 0.01% sarcosyl.
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.

Gene Information

• Gene Name: CPB2 carboxypeptidase B2 [ Homo sapiens (human) ]
• Official Symbol: CPB2
• Synonyms: CPB2; carboxypeptidase B2; CPU; PCPB; TAFI; carboxypeptidase B2; carboxypeptidase B-like protein; carboxypeptidase B2 (plasma); carboxypeptidase B2 (plasma, carboxypeptidase U); carboxypeptidase R; thrombin-activable fibrinolysis inhibitor; thrombin-activatable fibrinolysis inhibitor
• Gene ID: 1361
• mRNA Refseq: NM_001278541.1
• Protein Refseq: NP_001265470.1
• UniProt ID: Q96IY4