Recombinant Human CPE Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: CPE-4323H
• Product Overview: CPE MS Standard C13 and N15-labeled recombinant protein (NP_001864) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a member of the M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature peptidase. This peripheral membrane protein cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. This protein may also function independently of its peptidase activity, as a neurotrophic factor that promotes neuronal survival, and as a sorting receptor that binds to regulated secretory pathway proteins, including prohormones. Mutations in this gene are implicated in type 2 diabetes.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 53.15 kDa
• AA Sequence: MAGRGGSALLALCGALAACGWLLGA EAQEPGAPAAGMRRRRRLQQEDGIS FEYHRYPELREALVSVWLQCTAISR IYTVGRSFEGRELLVIELSDNPGVH EPGEPEFKYIGNMHGNEAVGRELLI FLAQYLCNEYQKGNETIVNLIHSTR IHIMPSLNPDGFEKAASQPGELKDW FVGRSNAQGIDLNRNFPDLDRIVYV NEKEGGPNNHLLKNMKKIVDQNTKL APETKAVIHWIMDIPFVLSANLHGG DLVANYPYDETRSGSAHEYSSSPDD AIFQSLARAYSSFNPAMSDPNRPPC RKNDDDSSFVDGTTNGGAWYSVPGG MQDFNYLSSNCFEITVELSCEKFPP EETLKTYWEDNKNSLISYLEQIHRG VKGFVRDLQGNPIANATISVEGIDH DVTSAKDGDYWRLLIPGNYKLTASA PGYLAITKKVAVPYSPAAGVDFELE SFSERKEEEKEELMEWWKMMSETLN FTRTRPLEQKLISEEDLAANDILDY KDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: CPE carboxypeptidase E [ Homo sapiens (human) ]
• Official Symbol: CPE
• Synonyms: CPE; carboxypeptidase E; carboxypeptidase H; cobalt stimulated chromaffin granule carboxypeptidase; enkephalin convertase; insulin granule associated carboxypeptidase; CPH; prohormone-processing carboxypeptidase; insulin granule-associated carboxypeptidase; cobalt-stimulated chromaffin granule carboxypeptidase
• Gene ID: 1363
• mRNA Refseq: NM_001873
• Protein Refseq: NP_001864
• MIM: 114855
• UniProt ID: P16870