Recombinant Human CSTB protein, His-tagged CSTB-204H

Recombinant Human CSTB protein, His-tagged

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Recombinant Human CSTB protein, His-tagged

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Cat.No. : CSTB-204H
Product Overview : Recombinant CSTB, fused to His-tag, was expressed in E.coli and purified by using conventional chromatography techniques.
Description : CSTB, also known as Cystatin B is an anti-protease implicated in myoclonus epilepsy, a degenerative disease of the central nervous system. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. This protein is able to form a dimer stabilized by noncovalent forces and is thought to play a role in protecting against the proteases leaking from lysosomes. In cells, CSTB is located in the lysosomes and the cytoplasm, but also in the nucleus.
Source : E.coli
Species : Human
Tag : His
Form : Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 50mM NaCl
Bio-activity : The IC50 value is < 3.0nM. The inhibitory function of Cystatin B on protease activity of papain was measured by a fluorometric assay using Z-FR-AMC at pH 7.5 at 25C.
Molecular Mass : 13 kDa (118aa) confirmed by MALDI-TOF
AA Sequence : MGSSHHHHHH SSGLVPRGSH MMCGAPSATQ PATAETQHIA DQVRSQLEEK ENKKFPVFKA VSFKSQVVAG TNYFIKVHVG DEDFVHLRVFQSLPHENKPL TLSNYQTNKA KHDELTYF
Endotoxin : < 1.0 EU per 1 microgram of protein (determined by LAL method)
Purity : > 95% by SDS - PAGE
Storage : Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles.
Concentration : 1 mg/ml (determined by Bradford assay)
Gene Name : CSTB cystatin B (stefin B) [ Homo sapiens ]
Official Symbol : CSTB
Synonyms : CSTB; cystatin B (stefin B); EPM1, STFB; cystatin-B; CST6; PME; CPI-B; liver thiol proteinase inhibitor; ULD; EPM1; STFB; EPM1A;
Gene ID : 1476
mRNA Refseq : NM_000100
Protein Refseq : NP_000091
MIM : 601145
UniProt ID : P04080
Chromosome Location : 21q22.3
Function : cysteine-type endopeptidase inhibitor activity; endopeptidase inhibitor activity; protease binding;

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