Recombinant Human CTLA4, Fc-tagged
Cat.No. : | CTLA4-28029TH |
Product Overview : | Human fusion protein homodimeric glycosylated CTLA4 produced in Sf9 insect cells. Each subunit is fused to a polypeptide linker to the Fc portion of Human IgG1. |
- Specification
- Gene Information
- Related Products
Description : | This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. |
Conjugation : | Fc |
Tissue specificity : | Widely expressed with highest levels in lymphoid tissues. |
Form : | Lyophilised:Reconstitute in sterile 18MOhm/cm water to not less than 100μg/ml, which can then be further diluted to other aqueous solutions. |
Purity : | >95% by SDS-PAGE |
Storage buffer : | Preservative: NoneNo additives |
Storage : | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
Sequences of amino acids : | The sequence of the amino acids was determined and was found to be: Lys-Ala-Met-His-Val. |
Sequence Similarities : | Contains 1 Ig-like V-type (immunoglobulin-like) domain. |
Gene Name : | CTLA4 cytotoxic T-lymphocyte-associated protein 4 [ Homo sapiens ] |
Official Symbol : | CTLA4 |
Synonyms : | CTLA4; cytotoxic T-lymphocyte-associated protein 4; celiac disease 3 , CELIAC3; cytotoxic T-lymphocyte protein 4; CD; CD28; CD152; GSE; ICOS; |
Gene ID : | 1493 |
mRNA Refseq : | NM_001037631 |
Protein Refseq : | NP_001032720 |
Uniprot ID : | P16410 |
Chromosome Location : | 2q33 |
Pathway : | Adaptive Immune System, organism-specific biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved biosystem; CTLA4 inhibitory signaling, organism-specific biosystem; Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem; |
Function : | protein binding; |
Products Types
◆ Recombinant Protein | ||
CTLA4-3229H | Recombinant Human CTLA4 protein(Met1-Phe162), rFc-tagged | +Inquiry |
CTLA4-024H | Recombinant Human CTLA4 Protein, C-His-tagged | +Inquiry |
Ctla4-650H | Recombinant Human Ctla4 Protein, Fc-tagged | +Inquiry |
CTLA4-257H | Active Recombinant Human CTLA4 Protein, His-Avi-tagged, Biotinylated | +Inquiry |
CTLA4-902R | Recombinant Rhesus Macaque CTLA4 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
CTLA4-1047CCL | Recombinant Cynomolgus CTLA4 cell lysate | +Inquiry |
CTLA4-2179MCL | Recombinant Mouse CTLA4 cell lysate | +Inquiry |
CTLA4-2526HCL | Recombinant Human CTLA4 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-1713 | CTLA4[Biotinylated]:B7-2 Inhibitor Screening Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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