Recombinant Human CTNS Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: CTNS-4113H
• Product Overview: CTNS MS Standard C13 and N15-labeled recombinant protein (NP_004928) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a seven-transmembrane domain protein that functions to transport cystine out of lysosomes. Its activity is driven by the H+ electrochemical gradient of the lysosomal membrane. Mutations in this gene cause cystinosis, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 41.6 kDa
• AA Sequence: MIRNWLTIFILFPLKLVEKCESSVS LTVPPVVKLENGSSTNVSLTLRPPL NATLVITFEITFRSKNITILELPDE VVVPPGVTNSSFQVTSQNVGQLTVY LHGNHSNQTGPRIRFLVIRSSAISI INQVIGWIYFVAWSISFYPQVIMNW RRKSVIGLSFDFVALNLTGFVAYSV FNIGLLWVPYIKEQFLLKYPNGVNP VNSNDVFFSLHAVVLTLIIIVQCCL YERGGQRVSWPAIGFLVLAWLFAFV TMIVAAVGVITWLQFLFCFSYIKLA VTLVKYFPQAYMNFYYKSTEGWSIG NVLLDFTGGSFSLLQMFLQSYNNDQ WTLIFGDPTKFGLGVFSIVFDVVFF IQHFCLYRKRPGYDQLNTRTRPLEQ KLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: CTNS cystinosin, lysosomal cystine transporter [ Homo sapiens (human) ]
• Official Symbol: CTNS
• Synonyms: CTNS; cystinosin, lysosomal cystine transporter; cystinosis, nephropathic; cystinosin; CTNS LSB; PQLC4; CTNS-LSB
• Gene ID: 1497
• mRNA Refseq: NM_004937
• Protein Refseq: NP_004928
• MIM: 606272
• UniProt ID: O60931