Recombinant Human CYP2B6 Protein, Myc/DDK-tagged, C13 and N15-labeled

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Recombinant Human CYP2B6 Protein, Myc/DDK-tagged, C13 and N15-labeled

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Cat.No. : CYP2B6-4861H
Product Overview : CYP2B6 MS Standard C13 and N15-labeled recombinant protein (NP_000758) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
Description : This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 56.1 kDa
AA Sequence : MELSVLLFLA LLTGLLLLLV QCHPNTHDRL PPGPRPLPLL GNLLQMDRRG LLKSFLRFRE KYGDVFTVHL GPRPVVMLCG VEAIREALVD KAEAFSGRGK IAMVDPFFRG YGVIFANGNR WKVLRRFSVT TMRDFGMGKR SVEERIQEEA QCLIEELRKS KGALMDPTFL FQSITANIIC SIVFGKRFHY QDQEFLKMLN LFYQTFSLIS SVFGQLFELF SGFLKYFPGA HRQVYKNLQE INAYIGHSVE KHRETLDPSA PKDLIDTYLL HMEKEKSNAH SEFSHQNLNL NTLSLFFAGT ETTSTTLRYG FLLMLKYPHV AERVYREIEQ VIGPHRPPEL HDRAKMPYTE AVIYEIQRFS DLLPMGVPHI VTQHTSFRGY IIPKDTEVFL ILSTALHDPH YFEKPDAFNP DHFLDANGAL KKTEAFIPFS LGKRICLGEG IARAELFLFF TTILQNFSMA SPVAPEDIDL TPQECGVGKI PPTYQIRFLP RTRTRPLEQK LISEEDLAAN DILDYKDDDD KV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
SDS-PAGE :

Gene Name : CYP2B6 cytochrome P450 family 2 subfamily B member 6 [ Homo sapiens (human) ]
Official Symbol : CYP2B6
Synonyms : CYP2B6; cytochrome P450, family 2, subfamily B, polypeptide 6; CYP2B, cytochrome P450, family 2, subfamily B, cytochrome P450, subfamily IIB (phenobarbital inducible), cytochrome P450, subfamily IIB (phenobarbital inducible), polypeptide 6; cytochrome P450 2B6; CPB6; CYPIIB6; cytochrome P450 IIB1; cytochrome P450, subfamily IIB (phenobarbital-inducible), polypeptide 6; EFVM; IIB1; P450; CYP2B; CYP2B7; CYP2B7P;
Gene ID : 1555
mRNA Refseq : NM_000767
Protein Refseq : NP_000758
MIM : 123930
UniProt ID : P20813

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