Expand Expand| Cat.No. : | D2HGDH-1657H |
| Product Overview : | Recombinant Human D2HGDH aa. (Arg56~Asp232 (Accession # Q8N465)) fused with N-terminal His & T7 tag was produced in E. coli cells. |
| Description : | This gene encodes D-2hydroxyglutarate dehydrogenase, a mitochondrial enzyme belonging to the FAD-binding oxidoreductase/transferase type 4 family. This enzyme, which is most active in liver and kidney but also active in heart and brain, converts D-2-hydroxyglutarate to 2-ketoglutarate. Mutations in this gene are present in D-2-hydroxyglutaric aciduria, a rare recessive neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features. |
| Source : | E. coli |
| Species : | Human |
| Tag : | His & T7 |
| Form : | Freeze-dried powder |
| Molecular Mass : | Predicted Molecular Mass: 22.8kDa |
| Protein length : | Arg56~Asp232 (Accession # Q8N465) |
| Endotoxin : | <1.0EU per 1ug (determined by the LAL method) |
| Purity : | >95% |
| Applications : | SDS-PAGE; WB; ELISA; IP. |
| Stability : | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
| Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. |
| Storage buffer : | Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl. |
| Reconstitution : | Reconstitute in sterile PBS, pH7.2-pH7.4. |
| Isoelectric Point : | 6.7 |
| Gene Name : | D2HGDH D-2-hydroxyglutarate dehydrogenase [ Homo sapiens (human) ] |
| Official Symbol : | D2HGDH |
| Synonyms : | D2HGDH; D-2-hydroxyglutarate dehydrogenase; D2HGD; D-2-hydroxyglutarate dehydrogenase, mitochondrial |
| Gene ID : | 728294 |
| mRNA Refseq : | NM_001287249.1 |
| Protein Refseq : | NP_001274178.1 |
| UniProt ID : | Q8N465 |
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