"D2HGDH" Related Products


Recombinant Human D2HGDH protein, His & T7-tagged

Cat.No. : D2HGDH-1657H
Product Overview : Recombinant Human D2HGDH aa. (Arg56~Asp232 (Accession # Q8N465)) fused with N-terminal His & T7 tag was produced in E. coli cells.
Description : This gene encodes D-2hydroxyglutarate dehydrogenase, a mitochondrial enzyme belonging to the FAD-binding oxidoreductase/transferase type 4 family. This enzyme, which is most active in liver and kidney but also active in heart and brain, converts D-2-hydroxyglutarate to 2-ketoglutarate. Mutations in this gene are present in D-2-hydroxyglutaric aciduria, a rare recessive neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features.
Source : E. coli
Species : Human
Tag : His & T7
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 22.8kDa
Protein length : Arg56~Asp232 (Accession # Q8N465)
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : >95%
Applications : SDS-PAGE; WB; ELISA; IP.
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage buffer : Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
Isoelectric Point : 6.7
Gene Name : D2HGDH D-2-hydroxyglutarate dehydrogenase [ Homo sapiens (human) ]
Official Symbol : D2HGDH
Synonyms : D2HGDH; D-2-hydroxyglutarate dehydrogenase; D2HGD; D-2-hydroxyglutarate dehydrogenase, mitochondrial
Gene ID : 728294
mRNA Refseq : NM_001287249.1
Protein Refseq : NP_001274178.1
UniProt ID : Q8N465

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