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Recombinant Human DAB2 Protein, GST-tagged

Cat.No. : DAB2-2315H
Product Overview : Human DAB2 full-length ORF ( AAH03064, 1 a.a. - 770 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
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Description : This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 110.22 kDa
AA Sequence : MSNEVETSATNGQPDQQAAPKAPSK KEKKKGPEKTDEYLLARFKGDGVKY KAKLIGIDDVPDARGDKMSQDSMMK LKGMAAAGRSQGQHKQRIWVNISLS GIKIIDEKTGVIEHEHPVNKISFIA RDVTDNRAFGYVCGGEGQHQFFAIK TGQQAEPLVVDLKDLFQVIYNVKKK EEEKKKIEEASKAVENGSEALMILD DQTNKLKSGVDQMDLFGDMSTPPDL NSPTESKDILLVDLNSEIDTNQNSL RENPFLTNGITSCSLPRPTPQASFL PENAFSANLNFFPTPNPDPFRDDPF TQPDQSTPSSFDSLKSPDQKKENSS SSSTPLSNGPLNGDVDYFGQQFDQI SNRTGKQEAQAGPWPFSSSQTQPAV RTQNGVSEREQNGFSVKSSPNPFVG SPPKGLSIQNGVKQDLESSVQSSPH DSIAIIPPPQSTKPGRGRRTAKSSA NDLLASDIFAPPVSEPSGQASPTGQ PTALQPNPLDLFKTSAPAPVGPLVG LGGVTVTLPQAGPWNTASLVFNQSP SMAPGAMMGGQPSGFSQPVIFGTSP AVSGWNQPSPFAASTPPPVPVVWGP SASVAPNAWSTTSPLGNPFQSNIFP APAVSTQPPSMHSSLLVTPPQPPPR AGPPKDISSDAFTALDPLGDKEIKD VKEMFKDFQLWQPPAVPARKGEQTS SGTLSAFASYFNSKVGIPQENADHD DFDANQLLNKINEPPKPAPRQVSLP VTKSTDNAFENPFFKDSFGSSQASV ASSQPVSSEMYRDPFGNPFA
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) [ Homo sapiens ]
Official Symbol : DAB2
Synonyms : DAB2; disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila); disabled (Drosophila) homolog 2 (mitogen responsive phosphoprotein); disabled homolog 2; DOC 2; differentially-expressed protein 2; DOC2; DOC-2; FLJ26626;
Gene ID : 1601
mRNA Refseq : NM_001244871
Protein Refseq : NP_001231800
MIM : 601236
UniProt ID : P98082

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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