Recombinant Human DCC Protein, MYC/DDK-tagged

• Cat.No.: DCC-1171H
• Product Overview: Recombinant human DCC protein, fused to MYC/DDK tag at C-terminus, was expressed in HEK293.

Specification

• Description: This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]
• Source: HEK293
• Species: Human
• Tag: MYC/DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
• Molecular Mass: 158.3 kDa
• Purity: >50 ug/mL as determined by microplate BCA method
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: DCC deleted in colorectal carcinoma [ Homo sapiens ]
• Official Symbol: DCC
• Synonyms: CRC18; CRCR1; IGDCC1; MRMV1; NTN1R1
• Gene ID: 1630
• mRNA Refseq: NM_005215
• Protein Refseq: NP_005206
• MIM: 120470
• UniProt ID: P43146