Recombinant Human DCLK2 Protein, GST-tagged


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Recombinant Human DCLK2 Protein, GST-tagged

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Cat.No. : DCLK2-2393H
Product Overview : Human DCLK2 (NP_689832.1, 1 a.a. - 695 a.a.) full-length recombinant protein with GST tag expressed in baculovirus infected Sf21 cells.
Description : This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Sep 2010]
Source : Insect Cells
Species : Human
Tag : GST
Form : Liquid
Bio-activity : The activity was measured by off-chip mobility shift assay. The enzyme was incubated with fluorescence-labeled substrate and Mg(or Mn)/ATP. The phosphorylated and unphosphorylated substrates were separated and detected by LabChip 3000. Substrate: GS peptide. ATP: 100 uM.
Molecular Mass : 103 kDa
Purity : 64 % by SDS-PAGE/CBB staining
Applications : Antibody Production
Functional Study
Compound Screening
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : In 50 mM Tris-HCl, 150 mM NaCl, pH 7.5 (0.1% CHAPS, 1 mM DTT, 10% glycerol)
Quality Control Testing: :

Loading 1 μg protein in SDS-PAGE

Result of activity analysis :

Gene Name : DCLK2 doublecortin-like kinase 2 [ Homo sapiens ]
Official Symbol : DCLK2
Synonyms : DCLK2; doublecortin-like kinase 2; DCAMKL2, doublecortin and CaM kinase like 2; serine/threonine-protein kinase DCLK2; DCDC3; DCDC3B; DCK2; MGC45428; CaMK-like CREB regulatory kinase 2; doublecortin and CaM kinase-like 2; doublecortin-like and CAM kinase-like 2; doublecortin domain-containing protein 3B; CL2; CLIK2; CLICK2; DCAMKL2; CLICK-II; DKFZp761I032;
Gene ID : 166614
mRNA Refseq : NM_001040260
Protein Refseq : NP_001035350
MIM : 613166
UniProt ID : Q8N568

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